Center for Depression Research and Clinical Care

The Center for Depression Research and Clinical Care (CDRC) at UT Southwestern Medical Center is nationally recognized for its cutting edge research in unipolar and bipolar depression. The research conducted within the center brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.

Learn more about our work by visiting Dr. Trivedi's lab website here.


Built on a quarter-century of research in mood disorders, the Center for Depression Research and Clinical Care (CDRC) was established in 2015 to realize a future free from the burden of depression. In the last seven years, our Center has demonstrated its impact in lives changed. We have lead research into new treatments, including brain and blood tests, for depression and suicide. We have established evidence-based programs that transform our ability to prevent, diagnose, and treat depression. Critically, we have built networks and established research-driven programs that extend our reach to adolescents; addressing youth depression and suicide with mental health promotion and resilience training that encourages a conversation long overdue. We have witnessed the difference our efforts make for people with mental disorders and their families. Such results speak to the value of the work to which we have dedicated ourselves.

Our Community

The Center for Depression Research and Clinical Care is continually striving to build bridges to better mental health and wellbeing for our community in Texas and beyond. Accomplishing this means addressing the particular needs and levels of community involvement that make success possible.

Learn more about our programs, here.



Our Research

For more than two decades, Dr. Madhukar Trivedi and his colleagues at UT Southwestern Medical Center have conducted cutting-edge research to improve the treatment of depression, including the largest study-to-date examining appropriate treatment sequences for depression.


Our Vision

A future free from the burden of depression.

Our path to success is based on 5-core objectives

Partner with the community to make depression treatment mainstream.

focus on an active approach, deliver services and treatment to people where they live, demystify depression

Teach resilience to empower prevention.

focus on giving adolescents knowledge and a vocabulary to talk about mental health, and the skills to develop a personalized mental health toolbox through our Youth Aware of Mental Health (YAM) program and our newest program, Blue Steel.

Train the trainers.

focus on VitalSign6 and YAM trainings through the CDRC Training Academy to build a future generation of depression problem-solvers

Blend patient experience with data and metrics to guide treatment and progress.

focus on incorporating measurement-based care in primary care and pediatric practices

Develop biomarkers to improve existing treatments and create new ones.

focus on precision medicine research


Contact Us

1440 Empire Central

Level 3 Mood Disorders

Dallas, TX 75247-9119

Office: 214-648-4357 


400 West Magnolia Ave.

Fort Worth, TX 76104

Office: 817-262-2761 



CDRC COVID-19 Research