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Meet the Nitschke Lab team.

Get to know our Principal Investigator and team of researchers at Jun Wu Lab.

Chemistry Nitschke Lab Our lab works with murine disease models and employs Biochemistry , Molecular and Cell Biology to investigate brain glycogen metabolism and related neurodegenerative diseases. Principal Investigators: Felix Nitschke, Ph.D. Specialty Areas: Glycogen metabolism Graduate Programs: Biological Chemistry Neuroscience Noch Lab The Noch Lab is a basic and translational research laboratory focused on identifying novel strategies to target metabolic vulnerabilities in glioma. Principal

syntheses of KDO have been described.2 Here, we describe a new route to KDO based on allylation of 2,3:4,5-di-O- isopropylidene-D-arabinose (2) with ethyl 2-(bromo- methy1)acrylate and indium.s The stereochemistry ofthis reaction is based on the work of Schmid? who reported allylations yielding products having erythro selectivity at the carbon with the newly generated hydroxyl group, relative to the hydroxyl group at C-2 of the aldoses, by using acetonide-protected aldoses. (1) For a

- ance than older chemotherapeutic agents. A good example of this is found in breast tumors with Her2/neu expression, where treatment with Herceptin® causes resistance over time by using pathways that bypass the Her2/neu receptor. Administration of a combination of monoclonal antibodies to multiple receptors, however, effec- tively reduced the tumor recurrence rates [4]. This synergistic effect can be achieved with a single nanomedicine formulation, by attaching differ- entially targeted

Surface energy induced patterning of organic and inorganic materials on heterogeneous Si surfaces L. Tao, A. Crouch, F. Yoon, and B. K. Lee Department of Electrical Engineering, University of Texas at Dallas, Richardson, Texas 75083 J. S. Guthi Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Texas 75390 J. Kim Department of Electrical Engineering, University of Texas at Dallas, Richardson, Texas 75083 J. Gao Simmons Comprehensive Cancer Center

Burgess Lab publications

towards eliminating Lafora disease from Miniature Wirehaired Dachshunds in the United Kingdom. Ahonen S, Seath I, Rusbridge C, Holt S, Key G, Wang T, Wang P, Minassian BA 2018 Canine Genet Epidemiol 5 2 Understanding the brain one amino acid at a time - The case of the FHF1 R52H encephalopathy. Minassian BA 2017 Sep Eur. J. Paediatr. Neurol. 5 21 699-700 Hyperventilation-athetosis in ASXL3 deficiency (Bainbridge-Ropers) syndrome. Dad R, Walker S, Scherer SW, Hassan MJ, Kang SY, Minassian BA 2017 Oct

anticancer drug, 5-fluorouracil (5- FU). The millirod consists of two functional compartments: (1) an inner 5-FU-loaded monolithic millirod as the drug depot, and (2) an outer NaCl-impregnated polymer mem- brane to control the release rate of 5-FU. The inner millirod is fabricated by a compression-heat molding procedure to permit the entrapment of 5-FU particles in the poly(D,L- lactide-co-glycolide) (PLGA) matrix. The drug loading den- sity is controlled at 30 w/w% to achieve a burst release of 5-FU