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STARS Summer Research Program for Teachers 2015 Corey Atkins Travis Elementary School Host: Connie Hsia, M.D. The Potential of Decellularized Extracellular Matrix as Treatment for Acute Lung Injury Mary Batalla Crockett Middle School Host: Avneesh Chhabra, M.D. Femoroacetabular Impingement: Is It a Hip or Lumbar Spine Problem? Jeff Bivins Richardson High School Host: Ralph Mason, Ph.D. Evaluating the Effects of Vascular Disrupting Agents on 4T1-wildtype Mouse Breast Tumor

Basic Science Symposia and In-services STARS offers Symposia and In-service Sessions each month, either on Monday evenings or Saturdays. Symposia feature scientists and physician-scientists discussing the very latest advances in biomedical research areas such as: • Mental Disorders/Neurological Diseases • Stem Cells • Pathogens/Microbes • Much more… Basic research topics are covered in areas such as: • Cell biology of diseases such as obesity and Alzheimer’s • Protein structure and

STARS Summer Research Program for Teachers 2014 Christine Cook Richland High School Host: Rueyling Lin, Ph.D. Effects of Caenorhabditis Elegans Dauer Specific Mol- ecules on the Th2-type Immune Response in Mammals Melissa Guerro Skyline High School Host: Yunsun Nam, Ph.D. In vitro Protein Synthesis of Drosha Constructs From Seven- teen Different Templates Carolyn Hess School of Health Professions at Yvonne A. Ewell Townview Center Host: Kimberly Huber, Ph.D. Effects of MEF2c

Acquired: Localized Localized lipodystrophies are defined as a localized loss of subcutaneous fat from small areas or from parts of a limb. There may be single or multiple lesions. It is characterized by depressed areas corresponding to the loss of subcutaneous fat. In some cases, it may be associated with tender, painful nodules in the skin. Usually, it occurs in diabetic patients at the site of insulin injections. In some patients, at loss occurs from areas where pressure is applied

Inherited: Neonatal Progeroid Syndrome (Wiedemann-Rautenstrauch syndrome) Neonatal progeroid syndrome (NPS), also known as Wiedemann- Rautenstrauch Syndrome, is a rare autosomal recessive disorder characterized by accelerated aging and lipodystrophy from birth. Affected children have extreme intrauterine growth retardation, poor postnatal weight gain, and have a characteristic progeroid face (triangular, old-looking face with a beak shaped or pinched nose), pseudohydrocephalus, wide

Medical Center STARS Summer Research Program for Students 2013 Dagem Adera Harmony Science Academy Host: Denise Marciano, M.D., Ph.D. Role of p120 Catenin in Regulating Glis2 Function Ivette Alvarez Peak Preparatory High School Host: Rana Gupta, Ph.D. Molecular Determinants of Brown and White Adipocyte Development Olatunde Badejo North Garland High School Host: Michael Shiloh, M.D., Ph.D. Discovering Peptide Sequences for Use in a Mimotope Vaccine Emily Barnes Episcopal School

Acquired: Partial Lipodystrophy (Barraquer-Simons Syndrome) The onset of acquired partial lipodystrophy usually occurs around 8-10 years of age and is usually preceded by an episode of acute viral infection. It is rare -approximately 250 patients of various ethnic origins have been described. It is characterized by the loss of fat from the face, extending to involve the neck, shoulders, arms, forearms, thoracic region and upper abdomen occasionally extending to the groin or thighs

Medical Center STARS Summer Research Program for Teachers 2012 Aaron Anderson Alex W. Spence Middle School Host: Chalermchai Khemtong, PhD The Effect of Exogenous Lactate Pool Size on Myocardial Metabolism of Pyruvate: A 13C NMR Isotopomer Study Bryan Bolster Bryan Adams High School Host: Nancy Monson, PhD Antibody genetics of myelin basic protein reactive B cells Elliot Charles Sunset High School Host: Orhan K. Oz, MD, PhD Development of a PET Imaging Probe for Noninvasive

Inherited: Familial Partial Lipodystrophies, other Types Familial Partial Lipodystrophy- PPAR gamma (Peroxisome Proliferator Activated Receptor- γ) gene mutations Only about twenty patients with FPL due to heterozygous mutation in PPARG have been reported so far. It is either much less common than FPL, Dunnigan variety or is less recognized likely due to milder phenotype. We recently reported heterozygous mutation (Arg397Cys) of peroxisome proliferator-activated receptor gamma