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Biotechnology in the Post- Genomic Age STARS Inservice on Biotechnology February 4, 2006 Joel M. Goodman, Ph.D. Supporting Cast  STARS support  Ms. Jeannie Han  Ms. Traydell Beard  Goodman lab support  Dr. Derk Binns  Ms. Kimberly Szymanski Activity 1: PCR  We’ll start this now, talk more later  You will be amplifying a yeast gene (one of five different genes) using the polymerase chain reaction.  6 groups, 4 teachers to a group  By the end of the day, you will identify

Introduction to Proteins and Enzymes • Basics of protein structure and composition • The life of a protein • Enzymes – Theory of enzyme function – Not all enzymes are proteins / not all proteins are enzymes – Enzyme REGULATION • Setting up an enzyme assay – Buffer, cofactors, substrate, enzyme Why are Proteins Important? • Major class of catalysts in the cells; responsible for metabolism • Proteins interconvert energy • Proteins permit selective import and export of molecules from

Better Living Through ChemistryBetter Living Through Chemistry Kurt C. Kleinschmidt, M.D.Kurt C. Kleinschmidt, M.D. Associate Professor of SurgeryAssociate Professor of Surgery Division of Emergency MedicineDivision of Emergency Medicine Faculty, Section of ToxicologyFaculty, Section of Toxicology University of Texas Southwestern Medical CenterUniversity of Texas Southwestern Medical Center Associate Medical Director, Emergency DepartmentAssociate Medical Director, Emergency Department

Renal Structure and Function Sodium Transport Orson W. Moe, M.D. Department of Internal Medicine Division of Nephrology UTSouthwestern STARS Program organism world Maintain constancy Composition Quantity Afferent Sensor Efferent Effector Physiologic parameter Disease Excretion Endocrine Metabolism Renal Function Good stuff Bad stuff Endocrine hormone Metabolic substrate Gross anatomy Medulla (Pyramids) Capsule Medullary rays Cortex Major calyx Minor calyx Renal

STARS A Valuable Resource for Health Science Teachers 2006 Health Science Technology Education Professional Development Conference July 19, 2006 Joel M. Goodman, Ph.D. Professor of Pharmacology STARS Director Today’s agenda Introduction to STARS Suture clinic What is STARS? • Science Teacher Access to Resources at Southwestern • Developed at UT Southwestern in 1991 to improve science teaching in north Texas. • Currently offer 17 programs and activities for secondary school

Protein Structure Determination An Introduction Chad A. Brautigam, Ph.D. Structural Biology Laboratory UTSW Medical Center at Dallas What is “Protein Structure?” …Arg-Lys-Ala-Gln-Trp-Cys-His-Ala-Asp… What is “Protein Structure?” • It is the description of the three- dimensional architecture of a polypeptide. • Our aim: to know accurately and precisely the position of every atom in a protein. That’s usually between 2000 and 10,000 atoms! Wherefore Art Thou, Protein

The Science & Epidemiology of Adolescent Poisonings Greene Shepherd, PharmD., DABATGreene Shepherd, PharmD., DABAT Managing Director & Clinical Assistant ProfessorManaging Director & Clinical Assistant Professor North Texas Poison Center & North Texas Poison Center & UTSW Division of Emergency MedicineUTSW Division of Emergency Medicine What Makes a Poison? •• The odor?The odor? •• The taste?The taste? •• The color?The color? •• The substance?The substance? –– Arsenic Arsenic vsvs

The Skeletal Response to Aging: There’s No Bones About It! April 7, 2001 Joseph E. Zerwekh, Ph.D. Interrelationship of Intestinal, Skeletal, and Renal Systems to the Overall Maintenance of Normal Calcium Homeostasis Blood Calcium Absorption (500 mg) Secretion (300 mg) Resorption (500 mg) Formation (500 mg) Filtration (8000 mg/d) Reabsorption (7800 mg/d) Dietary Ca (800 mg/d) in stool 200 mg lost in urine 600 mg lost 800 mg output Functions of the Human Skeleton • Protects

Medical ImagingMedical Imaging Gary Gary ArbiqueArbique, Ph.D., Ph.D. UTSW Medical Physics DivisionUTSW Medical Physics Division Medical Imaging Time LineMedical Imaging Time Line •• 1895 1895 -- First xFirst x--ray image of human handray image of human hand •• 1914 1914 -- First practical fluoroscopeFirst practical fluoroscope •• 1924 1924 -- BlumgartBlumgart & de & de HevesyHevesy perform first perform first clinical tracer studiesclinical tracer studies •• 1948 1948 –– Fluoroscopic

DR. WOODRING E. WRIGHT BIOLOGY OF AGING Learning objectives: At the completion of the lecture, you should be able to: 1. 2. 3. 4. 5. 6. 7. 8. 9. Define antagonistic pleiotropy Give the rationale for why the “disposable soma” theory of aging can be treated as an example of antagonistic pleiotropy Name four premature aging syndromes, two of which are known to affect DNA repair enzymes Describe why patients with diabetes are thought to show accelerated aging of