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Dissecting the Role of MeCP2 in Brain & Implications for Autism Spectrum Disorders Lisa M. Monteggia, Ph.D. Department of Psychiatry UT Southwestern Medical Center, Dallas, TX Autism • Twin studies examining the concordance of autism spectrum disorders for identical twins, compared to fraternal twins or siblings, indicates a strong genetic component. • Many genes have been associated with autism, but each has been found in only a few individuals. • No single

Antibiotics Joel Goodman STARS Minisymposium March 6, 2006 Outline • The spectrum of infectious agents and the global problem of human infections • Classification of bacteria • Intro to antibiotic classes, drug targets and resistance • Three antibiotics in detail – Sulfonamides – Penicillin – Streptomycin Statement by Dr. David L. Heymann Executive Director for Communicable Diseases World Health Organization Before the Committee on International Relations U.S. House of

Better Living Through ChemistryBetter Living Through Chemistry Kurt C. Kleinschmidt, M.D.Kurt C. Kleinschmidt, M.D. Associate Professor of SurgeryAssociate Professor of Surgery Division of Emergency MedicineDivision of Emergency Medicine Faculty, Section of ToxicologyFaculty, Section of Toxicology University of Texas Southwestern Medical CenterUniversity of Texas Southwestern Medical Center Associate Medical Director, Emergency DepartmentAssociate Medical Director, Emergency Department

1 Alzheimer’s Disease Joachim Herz STARS January 11, 2010 2 From: Medical Library of Utah Amyloid Plaques Neurofibrillary Tangles The Hallmarks of Alzheimer Disease 1906 First description of Alzheimer’s Disease 1984 George Glenner identifies the Aβ protein as the main component of amyloid plaques, giving birth to the amyloid hypothesis 1987 Cloning of the gene encoding the amyloid precursor protein (APP) 1991 Identification of mutations in the amyloid precursor protein in

Cardiovascular Alterations Team Basic Science Clinical Science Mature Countermeasure Space Radiation Human Health and Countermeasures Cardiovascular Alterations Team Radiation, Endothelial Cell Senescence, Accelerated Aging, and Atherosclerosis PI. Art Shoukas, Ph.D. Johns Hopkins University Effect of high energy particle irradiation on adhesiveness of vascular endothelium and its consequences for atherosclerosis PI: Dennis Kucik, M.D. The University of Alabama at

It’s no fluke! Using planarians to understand parasitic schistosomes Jim Collins Department of Pharmacology Outline I. Planarians as an experimental model II. Peptide hormones regulate planarian reproduction III. Lessons from planarians: stem cells in schistosomes IV. Conclusion: Schistosomiasis is a disease of stem cells Planarian Regeneration Morgan, T. H. Experimental studies of the regeneration of Planaria maculata. Arch. Entwm. Org. 7, 364–397 (1898

The Science & Epidemiology of Adolescent Poisonings Greene Shepherd, PharmD., DABATGreene Shepherd, PharmD., DABAT Managing Director & Clinical Assistant ProfessorManaging Director & Clinical Assistant Professor North Texas Poison Center & North Texas Poison Center & UTSW Division of Emergency MedicineUTSW Division of Emergency Medicine What Makes a Poison? •• The odor?The odor? •• The taste?The taste? •• The color?The color? •• The substance?The substance? –– Arsenic Arsenic vsvs