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The National Cutting Horse Association (NCHA) Celebrity Cutting Event raised $125,000 in support of UT Southwestern Fort Worth.

Greg Jenkins, M.D., Class of 1971, made a gift to endow a Professorship that reflects on his father’s exceptional legacy

UT Southwestern to expand cancer care in Fort Worth with a state-of-the-art Radiation Oncology facility

For Billy Rodriguez, UT Southwestern is more than a medical provider - it's a partner in health, and a cornerstone of his philanthropic vision.

Moncrief Cancer Institute saves lives by expanding early cancer detection across North Texas

The Mansfield Baseball Academy’s Horned Frogs recently partnered with UT Southwestern for the first time, raising funds to support the UT Southwestern DFW Adaptive Sports

9/12/16   1   STARS Mini-Symposium 9/12/2016 DNA Sequencing: The Past, the Present and the Future Ralf Kittler, Ph.D. McDermott Center for Human Growth and Development ralf.kittler@utsouthwestern.edu Outline DNA sequencing is a biochemical method to determine the sequence of the nucleotide bases that make up the DNA 1.   The Past – Sanger Sequencing 2.   The Present – Illumina Sequencing 3. The Future – Single Molecule Sequencing 9/12/16   2   Part 1 The past

Renal Structure and Function Sodium Transport Orson W. Moe, M.D. Department of Internal Medicine Division of Nephrology UTSouthwestern STARS Program organism world Maintain constancy Composition Quantity Afferent Sensor Efferent Effector Physiologic parameter Disease Excretion Endocrine Metabolism Renal Function Good stuff Bad stuff Endocrine hormone Metabolic substrate Gross anatomy Medulla (Pyramids) Capsule Medullary rays Cortex Major calyx Minor calyx Renal

Molecular Mechanisms of Circadian Clocks Circadian Rhythms • Endogenous rhythm which persists under constant conditions • Period of approximately 24 hours • Entrainable (reset) by environmental cues such as light and temperature • Temperature compensated - period stays about the same at different temperatures Circadian rhythm of locomoter activity Body temperature cycle Circadian rhythm of melatonin secretion Circadian rhythms of photosynthetic genes in plants

Introduction to Proteins and Enzymes • Basics of protein structure and composition • The life of a protein • Enzymes – Theory of enzyme function – Not all enzymes are proteins / not all proteins are enzymes – Enzyme REGULATION • Setting up an enzyme assay – Buffer, cofactors, substrate, enzyme Why are Proteins Important? • Major class of catalysts in the cells; responsible for metabolism • Proteins interconvert energy • Proteins permit selective import and export of molecules from