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Unravelling Autism • Preston Wiles M.D. • Professor, UTSWMC • Senior Attending, Autism Center Learning Objectives • Describe essential features of autism spectrum disorders • Overview of genetic factors in the disorder • Understand brain function related to core features of autism • Review features of epidemiology-is there an epidemic or not • Role of science/education vs. Myth/meme Autism Spectrum Disorders • Autistic Disorder • Pervasive Developmental

Jayanthi Lea, M.D., shares the latest on prevention and early detection of cervical and ovarian cancer during the 2022 Carolyn P. Horchow Women’s Health Symposium at UT Southwestern Medical Center.

Heather McArthur, M.D., shares new research on how the body's immune system can enhance breast cancer treatment during the 2022 Carolyn P. Horchow Women’s Health Symposium at UT Southwestern Medical Center.

Arlene Betancourt, M.D., Melissa Mauskar, M.D., and Ann Navar, M.D., Ph.D., present at the 2025 Carolyn P. Horchow Women’s Health Symposium at UT Southwestern Medical Center.

Osmosis and Osmoregulation Robert Alpern, M.D. Southwestern Medical School Water Transport Across Semipermeable Membranes • In a dilute solution, Jv = Lp (∆P - RΤ∆CS ) • Jv - volume or water flux • Lp - hydraulic conductivity or permeability • ∆P - hydrostatic pressure gradient • R - gas constant • T - absolute temperature (Kelvin) • ∆Cs - solute concentration gradient Osmotic Pressure • If Jv = 0, then ∆P = RT∆Cs van’t Hoff equation ∆Π

The Skeletal Response to Aging: There’s No Bones About It! April 7, 2001 Joseph E. Zerwekh, Ph.D. Interrelationship of Intestinal, Skeletal, and Renal Systems to the Overall Maintenance of Normal Calcium Homeostasis Blood Calcium Absorption (500 mg) Secretion (300 mg) Resorption (500 mg) Formation (500 mg) Filtration (8000 mg/d) Reabsorption (7800 mg/d) Dietary Ca (800 mg/d) in stool 200 mg lost in urine 600 mg lost 800 mg output Functions of the Human Skeleton • Protects

TYPE 2 DIABETES MELLITUS:TYPE 2 DIABETES MELLITUS: NEW HOPE FOR PREVENTIONNEW HOPE FOR PREVENTION Robert Dobbins, M.D. Ph.D.Robert Dobbins, M.D. Ph.D. Learning ObjectivesLearning Objectives Recognize current trends in the Recognize current trends in the prevalence of type 2 diabetes.prevalence of type 2 diabetes. Learn differences between type 1 Learn differences between type 1 and type 2 diabetes.and type 2 diabetes. List risk factors for type 2 diabetes.List risk factors for type 2

Protein Structure Determination An Introduction Chad A. Brautigam, Ph.D. Structural Biology Laboratory UTSW Medical Center at Dallas What is “Protein Structure?” …Arg-Lys-Ala-Gln-Trp-Cys-His-Ala-Asp… What is “Protein Structure?” • It is the description of the three- dimensional architecture of a polypeptide. • Our aim: to know accurately and precisely the position of every atom in a protein. That’s usually between 2000 and 10,000 atoms! Wherefore Art Thou, Protein