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Scientists have made remarkable advances toward developing effec- tive therapies for Alzheimer’s disease in the past year. There is a broad consensus now that amyloid and its most toxic form, Aß42, is directly responsible in part for the dementia of Alzheimer’s disease. Researchers in Iceland associated with the company deCODE Genetics have just reported that a rare muta- tion in the amyloid gene is sufficient to impair the conversion of the less toxic form of amyloid to its more

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MASS PROTEIN CHEMISTRY SPECTROMETRY TECHNOLOGY CENTER REQUISITION UTSWMC ND6.202; (214) 645-6300; (214) 645-6298 (fax) yli@biochem.swmed.edu Date Ordered: _____________________ Phone #: __________ Fax #: __________ Requested By: _____________________ Authorized Signature: _______________ Lab Room #: _____________________ Department: ______________________ Investigator: ______________________ PI: _______________________________ Sample Name Amt (pmol) Vol (µL) Est. Mwt (if known) Solution

EDMAN PROTEIN CHEMISTRY SEQUENCING TECHNOLOGY CENTER REQUISITION UTSWMC Y4.334; (214) 648 -5017; (214) 648-9477(fax) Bikash.Pramanik@UTSouthwestern.edu Date Ordered: _____________________ Phone #: __________ Fax #: __________ Requested By: _____________________ Authorized Signature: _______________ Lab Room #: _____________________ Department: ______________________ Investigator: ______________________ Acct #: ___________________________ No. Sample Name Amt (pmol) Est Mwt (if known) 1

2025 Carolyn P. Horchow Women’s Health Symposium Screening Before Symptoms and Sickness Rachel Bonnema, M.D., M.S. Professor of Internal Medicine Associate Chief, General Internal Medicine Distinguished Teaching Professor 2025 Carolyn P. Horchow Women’s Health Symposium 2 Outline • Breast Cancer – Risk assessment – Screening • Colon Cancer Screening • Cardiovascular Risk assessment – Cholesterol – Coronary artery calcium score (CAC score) 2025 Carolyn P. Horchow Women’s

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Kimberly Kho, M.D., presents at the 2018 Carol P. Horchow Women’s Health Symposium at UT Southwester Medical Center.