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7/27/25, 6:25 PM Page 1 of 1https://outlook.office.com/mail/inbox/id/AAQkAGU5YzExMDA2LWFj…EtNDk0OS04YzhhLWE0YTNlOGQ4MzEzNAAQAD4ct8Sg2LhElVP5TbZpjAg%3D Outlook The UTSW Insider | Monday, July 21, 2025 From UTSW Insider <utswinsider@utsouthwestern.edu> Date Mon 7/21/2025 7:02 AM To John Maxwell <John.Maxwell@UTSouthwestern.edu> Coming soon: New UTSW Service Center portal The UT Southwestern Information Resources (IR) team is excited to introduce the new UTSW Service Center portal, which is

12/18/24, 3:33 PM Page 1 of 1https://outlook.office.com/mail/inbox/id/AAQkAGU5YzExMDA2LWF…Dk0OS04YzhhLWE0YTNlOGQ4MzEzNAAQALPKc3U4mpFCtgo%2FUIt0VFM%3D Outlook The UTSW Insider | Wednesday, Dec. 18, 2024 From UTSW Insider <utswinsider@utsouthwestern.edu> Date Wed 12/18/2024 7:02 AM To John Maxwell <John.Maxwell@UTSouthwestern.edu> #ICYMI: Listen to the last campus briefing of 2024 IN CASE YOU MISSED IT Did you miss last week’s final campus briefing of the year by President Daniel K

• Scan in photos of orcas feeding on great whales • Know there are lots of orcas in the north Pacific A Life without Oxygen: The Physiology of Marine Mammals <Picture> COMPETITION FOR RESOURCES How marine mammals do what they do! Dive Response • Stop Breathing • ↓ Cardiac Output • ↓ Peripheral Blood Flow • Lungs Collapse below 60m • But Maintain Aerobic Metabolism Adaptations to Maintain Aerobic Metabolism under Hypoxic

Skeletal Muscle and Aging: Going, Going, Gone National Science Teachers Association 53rd National Convention April 2, 2005 20 yr 80 yr (http://www.sarcopenia.com/) Conditions Leading to Muscle Wasting (Atrophy) • Limb immobilization (casting) • Microgravity • Prolonged bed rest/hindlimb suspension • Tumor bearing • Fasting/malnutrition • Burns • Infection • Denervation • Sarcopenia Sarcopenia “No decline with age is more dramatic or potentially more functionally significant that

Medical ImagingMedical Imaging Gary Gary ArbiqueArbique, Ph.D., Ph.D. UTSW Medical Physics DivisionUTSW Medical Physics Division Medical Imaging Time LineMedical Imaging Time Line •• 1895 1895 -- First xFirst x--ray image of human handray image of human hand •• 1914 1914 -- First practical fluoroscopeFirst practical fluoroscope •• 1924 1924 -- BlumgartBlumgart & de & de HevesyHevesy perform first perform first clinical tracer studiesclinical tracer studies •• 1948 1948 –– Fluoroscopic

Introduction to Proteins and Enzymes • Basics of protein structure and composition • The life of a protein • Enzymes – Theory of enzyme function – Not all enzymes are proteins / not all proteins are enzymes – Enzyme REGULATION • Setting up an enzyme assay – Buffer, cofactors, substrate, enzyme Why are Proteins Important? • Major class of catalysts in the cells; responsible for metabolism • Proteins interconvert energy • Proteins permit selective import and export of molecules from

ß-Lapachone, a ‘Kiss of death’ therapy for cancer David A. Boothman, Ph.D. Laboratory of Molecular Stress Responses Program in Cell Stress and Cancer Nanomedicine Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center at Dallas September 14, 2008 Cellular Damage New Gene Expression Exploitable Target: Expressed in Human Tumors, not (or low) in Normal Tissues Bioactivate Drug For Tumor-Selective Killing -Not cell cycle

Protein Structure Determination An Introduction Chad A. Brautigam, Ph.D. Structural Biology Laboratory UTSW Medical Center at Dallas What is “Protein Structure?” …Arg-Lys-Ala-Gln-Trp-Cys-His-Ala-Asp… What is “Protein Structure?” • It is the description of the three- dimensional architecture of a polypeptide. • Our aim: to know accurately and precisely the position of every atom in a protein. That’s usually between 2000 and 10,000 atoms! Wherefore Art Thou, Protein

STARS A Valuable Resource for Health Science Teachers 2006 Health Science Technology Education Professional Development Conference July 19, 2006 Joel M. Goodman, Ph.D. Professor of Pharmacology STARS Director Today’s agenda Introduction to STARS Suture clinic What is STARS? • Science Teacher Access to Resources at Southwestern • Developed at UT Southwestern in 1991 to improve science teaching in north Texas. • Currently offer 17 programs and activities for secondary school

1 Cancer Cancer NanomedicineNanomedicine JinmingJinming GaoGao, Ph.D., Ph.D. Department of PharmacologyDepartment of Pharmacology Harold C. Simmons Comprehensive Cancer CenterHarold C. Simmons Comprehensive Cancer Center UT Southwestern Medical CenterUT Southwestern Medical Center Departments of Chemistry and BioengineeringDepartments of Chemistry and Bioengineering UT DallasUT Dallas 12,75612,756 kmkm NanomedicineNanomedicine in in PerspectivePerspective Mother EarthMother Earth 25.4