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How we use animal studies to understand recovery from brain injury Ann M. Stowe, PhD Assistant Professor Neurology & Neurotherapeutics Overview  Introduction to clinical stroke  Post-stroke plasticity in non-human primates  Stroke models in rodents  Methods to promote recovery after stroke  Educational resources for the use of animals in biomedical research General considerations  The brain is highly aerobic tissue  Dependent upon a steady supply of

Skeletal Muscle and Aging: Going, Going, Gone National Science Teachers Association 53rd National Convention April 2, 2005 20 yr 80 yr (http://www.sarcopenia.com/) Conditions Leading to Muscle Wasting (Atrophy) • Limb immobilization (casting) • Microgravity • Prolonged bed rest/hindlimb suspension • Tumor bearing • Fasting/malnutrition • Burns • Infection • Denervation • Sarcopenia Sarcopenia “No decline with age is more dramatic or potentially more functionally significant that

Clinical Aspects of Hyponatremia & Hypernatremia Case Presentation: History 62 y/o male is admitted to the hospital with a 3 month history of excessive urination (polyuria) and excess water intake up to a gallon per day. His wife noted that he had lost weight, became forgetful and irascible. Case Presentation: Physical Examination Emaciated, somnolent 62 y/o man in no acute distress. Multiple signs of dehydration were evident including low blood pressure upon standing (orthostatic

Population Genetics, Population Genetics, SystematicsSystematics and and Conservation of Endangered SpeciesConservation of Endangered Species Discuss Discuss Population GeneticsPopulation Genetics and and SystematicsSystematics Describe how DNA is used in species managementDescribe how DNA is used in species management Wild vs. Captive populationsWild vs. Captive populations Data Generation:Data Generation: PCR / Fragment AnalysisPCR / Fragment Analysis DNA SequencingDNA Sequencing Data

The Science Of Anabolic Steroid Abuse Richard J. Auchus, MD, PhD Division of Endocrinology & Metabolism UT Southwestern Medical Center Dallas, TX Androgens As Anabolic Agents Myths • Used Mostly By Professional Athletes – ….Well, Maybe Intense Bodybuilders…. • Users Die of Cancer, Liver Failure, Strokes – ….But Androgens Are Not Like Narcotics…. • It Is Not Germane To My Practice • Have No Place In Good Medical Practice Androgens As Anabolic Agents Reality • Common In General

A. Axial T2-weighted MRI scan through the lateral ventricles of the brain reveals abnormal high signal intensity within the corticospinal tracts (arrows). B. Axial T2- weighted image through the level of the internal capsules reveals abnormal foci of high singal intensity in the posterior limbs of the internal capsule (arrows). This MRI feature represents an increase in water content in myelin tracts undergoing Wallerian degeneration secondary to cortical neuronal loss. This finding is commonly

How is the brain influenced by radiation? Amelia J. Eisch, Ph.D. Department of Psychiatry, UT Southwestern October 3, 2009 Presenter Presentation Notes Here I will review the efforts of my laboratory, the dept of psychiatry in general, and the larger stem cell community at UT Southwestern to move from correlative to causative studies. Novel mouse model, unpublished and recently published data, movies of how we model these disorders in laboratory animals. Fike, Limoli, and Raber Why does

TYPE 2 DIABETES MELLITUS:TYPE 2 DIABETES MELLITUS: NEW HOPE FOR PREVENTIONNEW HOPE FOR PREVENTION Robert Dobbins, M.D. Ph.D.Robert Dobbins, M.D. Ph.D. Learning ObjectivesLearning Objectives Recognize current trends in the Recognize current trends in the prevalence of type 2 diabetes.prevalence of type 2 diabetes. Learn differences between type 1 Learn differences between type 1 and type 2 diabetes.and type 2 diabetes. List risk factors for type 2 diabetes.List risk factors for type 2