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Anti-malarial Drug Discovery Jeffrey Baldwin, PhD UT Southwestern Medical Center Department of Pharmacology Malaria Burden Life Cycle Jones & Good, Nature Medicine (Feb. 2006) Complex life cycle Intracellular parasite Pathogenesis 4 Plasmodium species are human pathogens: Falciparum Vivax Ovale Malariae Miller et al, Nature (7 Feb, 2002) Clinical Outcomes Miller et al, Nature (7 Feb, 2002) Immune Evasion PfEMP1 is key to lethality of P. falciparum Sticky molecules evade

Watch videos from the 2022 Carolyn P. Horchow Women’s Health Symposium

Watch videos from the 2023 Carolyn P. Horchow Women’s Health Symposium

UT Southwestern to expand cancer care in Fort Worth with a state-of-the-art Radiation Oncology facility

ß-Lapachone, a ‘Kiss of death’ therapy for cancer David A. Boothman, Ph.D. Laboratory of Molecular Stress Responses Program in Cell Stress and Cancer Nanomedicine Simmons Comprehensive Cancer Center University of Texas Southwestern Medical Center at Dallas September 14, 2008 Cellular Damage New Gene Expression Exploitable Target: Expressed in Human Tumors, not (or low) in Normal Tissues Bioactivate Drug For Tumor-Selective Killing -Not cell cycle

Stroke:Stroke: Incidence and Cost in the United StatesIncidence and Cost in the United States ◆ 700,000 new cases yearly ◆ #3 cause of death ◆ $43 billion annual health cost (1998) ◆ 4,400,000 stroke survivors at high risk for recurrence Most strokes can be prevented Cost of StrokeCost of Stroke ◆ Stroke severity includes a broad range; about half of survivors unable to walk unaided. ◆ Acute inpatient costs average $38,000 but are only a fraction of total economic burden (including

WEIGHT REGULATION AND THE ROLE OF LEPTIN J. Denis McGarry, Ph.D. A portion of this outline has been taken, with permission, from a Medical Grand Rounds lecture on the genetics of obesity given by Rody Cox, M.D. at U.T. Southwestern, March 7, 1996. Obesity has become a world-wide epidemic, particularly in developed countries. It is associated with a number of serious morbidities, including Type 2 diabetes, osteoarthritis and hypertension. The current cost of obesity/Type 2 diabetes syndromes