#!/usr/bin/perl   open(FILE,  "accepted_hits_sorted.sam")  or  die("Unable  to  open  file");   open(OUTPUT,  ">final-­‐alignment.sam")  or  die("Unable  to  open  file");     use  strict;   my  $i;   my  $line;   my  $line1;   my  @group;   my  @sam_coord;   my  @sam_coord0;   my  @ID0;   my  @sam_coord1;   my  @ID1;   my  @record;   my  $j;   my  @as0;   my  @as;   my  $index;   my  $maxval;   my

Meet our Principal Investigator, Emre Erol Turer, M.D., Ph.D.

Oxidation of Unsaturated Systems 2 general reactivity patterns: X H X Yn+2 X+ Yn ++ OH simple example O A- Me2SCl+ S+ O + S + Cl- 2 electron oxidation 1 electron oxidation Xor -1 e- or X we will focus on oxidation of aromatic rings and enol/enolate systems Couple Eo Fe(III) + e- Fe(II) 0.77 V(V) + e- V(IV) 1.00 Tl(III) + 2 e- Th(I) 1.25 Pb(IV) + 2 e- Pb(II) 1.6-1.7 Mn(III) + e- 1.56Mn(II) Ce(IV) + e- Ce(III) 1.6 Reduction potentials of oxidants we will look at (bigger number

Meet the Turer Lab team

Reductions General Resource: Trost, Comp. Org. Syn. 1991, vol 8 March,1992, chap 19 Carey and Sundberg, vol B, Chap 5 Smith, Organic Synthesis, Chap 4 Material organized (roughly) by transformation From March, 1992, p1208 H H Two general classes: Transition metal hydrogenation and dissolving metal reduction Hydrogenation: Covered in much more detail in Advanced Synthesis and Catalysis. H HM H2 General trends: more substituted = slower relationship of pressure:rate often not simple

Trivedi Lab's CDRC BioBank

Research opportunities for UT Southwestern's Cyclotron and Radiochemistry Program adult core.

ARTICLE Received 23 May 2016 | Accepted 13 Sep 2016 | Published 27 Oct 2016 Molecular basis of cooperativity in pH-triggered supramolecular self-assembly Yang Li1, Tian Zhao1, Chensu Wang1,2, Zhiqiang Lin1, Gang Huang1, Baran D. Sumer3 & Jinming Gao1 Supramolecular self-assembly offers a powerful strategy to produce high-performance, stimuli-responsive nanomaterials. However, lack of molecular understanding of stimulated responses frequently hampers our ability to rationally design

Our lab uses a combination of electrophysiological and molecular techniques to examine functions sub-served by these states at the cellular and circuit levels.

Substrate pKa's. Numbers are approximations for outside the range -2 - 16, but useful to know. For an extensive list, see http://www.chem.wisc.edu/areas/reich/pkatable/ Inorganics H2O DMSO CF3SO3H -14 HCl -8 H3O+ -2 H2O 16 NH4Cl 9 Organic X-H AcOH 5 12 O+ CH3Ph H -6 Me2OH+ -4 CH3SO3H -3 2 NH+ 5 3 N H O H 15 26 MeOH 16 28 17 29 NH3 36 38 41 EWG-CH NO2-CH3 10 17 O O 9 13 O EtO O 11 14 O EtO OEt O 13 16 O 20 27 O t-BuO 25 30 O Me2N 35 O S 3533PhOH 10 18