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Correlation between the Charge of Proteins in Solution and in the Gas Phase Investigated by Protein Charge Ladders, Capillary Electrophoresis, and Electrospray Ionization Mass Spectrometry Jeffrey D. Carbeck,† Joanne C. Severs,‡ Jinming Gao,† Qinyuan Wu,‡ Richard D. Smith,* ,‡ and George M. Whitesides*,† Department of Chemistry and Chemical Biology, HarVard UniVersity, 12 Oxford Street, Cambridge, Massachusetts 02138, and EnVironmental Molecular Science Laboratory, Pacific Northwest National

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Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods Feng Qian, Agata Szymanski, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Received 18 August 2000; accepted 5 October 2000 Abstract: A compression–heat molding procedure was de- veloped to fabricate poly(D,L-lactide-co-glycolide) (PLGA) controlled release drug delivery devices

Journal of Controlled Release 91 (2003) 157–166 www.elsevier.com/ locate/ jconrel Q uantification of in vivo doxorubicin transport from PLGA millirods in thermoablated rat livers a ,1 b a a a ,*Feng Qian , Nicholas Stowe , Erin H. Liu , Gerald M. Saidel , Jinming Gao aDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106,USA bDepartment of Surgery, Case Western Reserve University School of Medicine, Cleveland, OH 44106,USA Received 31 October 2002

COMMUNICATIONS Surface Modification of Polyanhydride Microspheres JINMING GAO†,‡, LAURA NIKLASON†,‡, XIAO-MEI ZHAO§, AND ROBERT LANGER*,† Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Anesthesia, Massachusetts General Hospital, Boston, Massachusetts 02114, and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 Received July 25, 1997. Final revised manuscript received

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Translational scientists search to understand the underlying mechanisms of disease pathology as well as therapeutic interventions.

Journal of Controlled Release 83 (2002) 415–425 www.elsevier.com/ locate/ jconrel N oninvasive monitoring of local drug release in a rabbit radiofrequency (RF) ablation model using X-ray computed tomography a b a aAgata Szymanski-Exner , Nicholas T. Stowe , Roee S. Lazebnik , Kyle Salem , a c a,c ,*David L. Wilson , John R. Haaga , Jinming Gao aDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106,USA bDepartment of Surgery, Case Western Reserve

Enhancement of Solubility and Bioavailability of �-Lapachone Using Cyclodextrin Inclusion Complexes Norased Nasongkla,1,2 Andy F. Wiedmann,2 Andrew Bruening,3 Meghan Beman,3 Dale Ray,4 William G. Bornmann,5 David A. Boothman,3 and Jinming Gao2,6 Received June 11, 2003; Accepted June 19, 2003 Purpose. To explore the use of cyclodextrins (CD) to form inclusion complexes with �-lapachone (�-lap) to overcome solubility and bio- availability problems previously noted with this drug. Methods

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