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Membrane-encased polymer millirods for sustained release of 5-fluorouracil Feng Qian, Norased Nasongkla, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Received 10 November 2001; revised 26 November 2001; accepted 26 November 2001 Abstract: This article describes the design and develop- ment of a novel membrane-encased polymer millirod for the sustained release of an

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©200 5 L ANDES BIOSCI EN CE. DO NOT D IST RIBUTE. [Cancer Biology & Therapy 4:1, 95-102, January 2005]; ©2005 Landes Bioscience Matthew Ough4 Anne Lewis4 Erik A. Bey6 Jinming Gao6 Justine M. Ritchie3 William Bornmann7 David A. Boothman6 Larry W. Oberley2,3,4 Joseph J. Cullen1,2,3,4,5,* Departments of 1Surgery, 2Radiation Oncology and the 3Holden Comprehensive Cancer Center; 4University of Iowa College of Medicine; Iowa City, Iowa USA 5Veterans Affairs Medical Center; Iowa City

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B � p o A r c B O S 6 P Int. J. Radiation Oncology Biol. Phys., Vol. 61, No. 1, pp. 212–219, 2005 Copyright © 2005 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/05/$–see front matter doi:10.1016/j.ijrobp.2004.09.018 IOLOGY CONTRIBUTION SUSCEPTIBILITY OF CANCER CELLS TO �-LAPACHONE IS ENHANCED BY IONIZING RADIATION HEON JOO PARK, M.D., PH.D.,*† KI-JUNG AHN, M.D.,* SEUNG-DO AHN, M.D.,‡ EUNKYUNG CHOI, M.D., PH.D.,‡ SANG WOOK LEE, M.D.,‡ BRENT WILLIAMS, B.S.,* EUN JUNG KIM