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ARTICLE Received 23 Jan 2015 | Accepted 1 Sep 2015 | Published 5 Oct 2015 A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles Chensu Wang1,2, Yiguang Wang1, Yang Li1, Brian Bodemann2, Tian Zhao1, Xinpeng Ma1, Gang Huang1, Zeping Hu3, Ralph J. DeBerardinis3, Michael A. White2 & Jinming Gao1 Endosomes, lysosomes and related catabolic organelles are a dynamic continuum of vacuolar structures that impact a number of cell physiological processes such as

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© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 1wileyonlinelibrary.com C o m m u n ic a tio n Digitization of Endocytic pH by Hybrid Ultra-pH-Sensitive Nanoprobes at Single-Organelle Resolution Yiguang Wang,* Chensu Wang, Yang Li, Gang Huang, Tian Zhao, Xinpeng Ma, Zhaohui Wang, Baran D. Sumer, Michael A. White, and Jinming Gao* Dr. Y. Wang, C. Wang, Y. Li, Dr. G. Huang, Dr. T. Zhao, Dr. X. Ma, Dr. Z. Wang, Prof. J. Gao Department of Pharmacology Simmons Comprehensive Cancer

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ARTICLE Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan Chensu Wang1,2, Hanspeter Niederstrasser3, Peter M. Douglas4, Rueyling Lin4, Juan Jaramillo4, Yang Li1, Nathaniel W. Olswald3, Anwu Zhou3, Elizabeth A. McMillan2, Saurabh Mendiratta2, Zhaohui Wang1, Tian Zhao1, Zhiqaing Lin1, Min Luo1, Gang Huang1, Rolf A. Brekken1,5, Bruce A. Posner3, John B. MacMillan3, Jinming Gao1 & Michael A. White2 Drugs that mirror the cellular

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