J O U R N A L O F M A T E R I A L S S C I E N C E 3 9 (2 0 0 4 ) 1429 – 1432 Size-controlled polyelectrolyte nanocapsules via layer-by-layer self-assembly H. AI , J . GAO Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 E-mail: jinming@cwru.edu Nanomaterials have found many important applica- tions in biomedical, pharmaceutical, electronic, and molecular diagnostic fields. The recent introduction of electrostatic layer-by-layer (LbL) self-assembly

Local carboplatin delivery and tissue distribution in livers after radiofrequency ablation A. Szymanski-Exner,1 A. Gallacher,2 N. T. Stowe,3 B. Weinberg,1 J. R. Haaga,4 J. Gao1,4 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 2Department of Analytical Chemistry, Ricerca, LLC, Concord, Ohio 3Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 4Department of Radiology, University Hospitals of

©200 5 L ANDES BIOSCI EN CE. DO NOT D IST RIBUTE. [Cancer Biology & Therapy 4:1, 95-102, January 2005]; ©2005 Landes Bioscience Matthew Ough4 Anne Lewis4 Erik A. Bey6 Jinming Gao6 Justine M. Ritchie3 William Bornmann7 David A. Boothman6 Larry W. Oberley2,3,4 Joseph J. Cullen1,2,3,4,5,* Departments of 1Surgery, 2Radiation Oncology and the 3Holden Comprehensive Cancer Center; 4University of Iowa College of Medicine; Iowa City, Iowa USA 5Veterans Affairs Medical Center; Iowa City

Original Investigations Quantitative Computed Tomography Analysis of Local Chemotherapy in Liver Tissue After Radiofrequency Ablation1 Agata A. Exner, PhD, Brent D. Weinberg, BS, Nicholas T. Stowe, PhD, Anthony Gallacher, MS, David L. Wilson, PhD, John R. Haaga, MD, Jinming Gao, PhD Rationale and Objectives. Computed tomography (CT) was used to noninvasively monitor local drug pharmacokinetics from polymer implants in rat livers before and following radiofrequency ablation. Materials and

Interactions between self-assembled polyelectrolyte shells and tumor cells Hua Ai,1 John J. Pink,2 Xintao Shuai,1 David A. Boothman,2 Jinming Gao1 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 2Department of Radiation Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106 Received 23 August 2004; revised 22 November 2004; accepted 23 November 2004 Published online 1 April 2005 in

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Local release of dexamethasone from polymer millirods effectively prevents fibrosis after radiofrequency ablation Elvin Blanco,1* Brent D. Weinberg,1 Nicholas T. Stowe,2 James M. Anderson,3 Jinming Gao1* 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 3Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

B � p o A r c B O S 6 P Int. J. Radiation Oncology Biol. Phys., Vol. 61, No. 1, pp. 212–219, 2005 Copyright © 2005 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/05/$–see front matter doi:10.1016/j.ijrobp.2004.09.018 IOLOGY CONTRIBUTION SUSCEPTIBILITY OF CANCER CELLS TO �-LAPACHONE IS ENHANCED BY IONIZING RADIATION HEON JOO PARK, M.D., PH.D.,*† KI-JUNG AHN, M.D.,* SEUNG-DO AHN, M.D.,‡ EUNKYUNG CHOI, M.D., PH.D.,‡ SANG WOOK LEE, M.D.,‡ BRENT WILLIAMS, B.S.,* EUN JUNG KIM

Poly(D, L-lactide-co-glycolide)/Poly(ethylenimine) Blend Matrix System for pH Sensitive Drug Delivery Damon Sutton, Remy Durand, Xintao Shuai,† Jinming Gao* Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 Received 29 April 2005; accepted 14 July 2005 DOI 10.1002/app.22636 Published online 9 January 2006 in Wiley InterScience (www.interscience.wiley.com). ABSTRACT: Poly(d,l-lactide-co-glycolide) (PLGA) and poly(ethylenimine) (PEI) were blended and

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