Enhancement of Solubility and Bioavailability of �-Lapachone Using Cyclodextrin Inclusion Complexes Norased Nasongkla,1,2 Andy F. Wiedmann,2 Andrew Bruening,3 Meghan Beman,3 Dale Ray,4 William G. Bornmann,5 David A. Boothman,3 and Jinming Gao2,6 Received June 11, 2003; Accepted June 19, 2003 Purpose. To explore the use of cyclodextrins (CD) to form inclusion complexes with �-lapachone (�-lap) to overcome solubility and bio- availability problems previously noted with this drug. Methods

Willed body programs, such as the one at UT Texas Southwestern Medical Center, help meet the growing need for human bodies for medical education and research.

Noncovalent Polycationic Coatings for Capillaries in Capillary Electrophoresis of Proteins Emilio Córdova, Jinming Gao, and George M. Whitesides* Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 The adsorption of proteins with net positive charges (pI > pH) on the walls of fused-silica capillaries is a common problem in the analysis of proteins by capillary electro- phoresis. This paper explores the use of polycationic

10 to 70% methanol in 50 mM KH2PO4 over 25 min, 10 ml/min, monitor at 380 nm). Next, the HPLC- purified mixture was desalted on the same column (methanol was removed on a rotary evaporator, and the sample loaded in H2O and eluted with 90% methanol) and lyophilized, yielding the purified Nvoc-aa-S-CoA (40 to 80% yield) as a yellow solid. For preparation of the deprotected aa-S-CoAs, the solution of Nvoc-aa-S-CoA collected from the HPLC purification was directly photolysed (4°C, 350 nm, 1 hour

Membrane-encased polymer millirods for sustained release of 5-fluorouracil Feng Qian, Norased Nasongkla, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Received 10 November 2001; revised 26 November 2001; accepted 26 November 2001 Abstract: This article describes the design and develop- ment of a novel membrane-encased polymer millirod for the sustained release of an

Journal of Controlled Release 83 (2002) 427–435 www.elsevier.com/ locate/ jconrel C ombined modeling and experimental approach for the development of dual-release polymer millirods *Feng Qian, Gerald M. Saidel, Damon M. Sutton, Agata Exner, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106,USA Received 3 July 2002; accepted 7 August 2002 Abstract This paper describes a

Bioorganic Chemistry cRGD-Functionalized Polymer Micelles for Targeted Doxorubicin Delivery** Norased Nasongkla, Xintao Shuai, Hua Ai, Brent D. Weinberg, John Pink, David A. Boothman, and Jinming Gao* Low water solubility, rapid phagocytic and renal clearance, and systemic toxicity represent three major barriers that limit the therapeutic use of many hydrophobic antitumor agents such as doxorubicin (DOXO) and paclitaxel.[1] Various drug- delivery systems, among which polymeric micelles have

JOURNAL OF RAMAN SPECTROSCOPY, VOL. 27, 549-554 (1996) Structure Characterization of W03/Zr02 Catalysts by Raman Spectroscopy Biying Zhao,* Xianping Xu, Jinming Gao, Qiang Fu and Youqi Tang Institute of Physical Chemistry, Peking University, Beijing 100871, China WO,/ZrO, catalysts prepared by different methods are distinct in their catalytic behaviour. In this work, WO,/ZrO, catalysts prepared by impregnating Zr(OH), and crystallized ZrO, and then calcining at selected temperatures

Subscriber access provided by UNIV TEXAS SW MEDICAL CENTER The Journal of Organic Chemistry is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Synthesis of KDO Using Indium-Mediated Allylation of 2,3:4,5-Di-O-isopropylidene-D-arabinose in Aqueous Media Jinming Gao, Ralph Haerter, Dana M. Gordon, and George M. Whitesides J. Org. Chem., 1994, 59 (13), 3714-3715• DOI: 10.1021/jo00092a040 • Publication Date (Web): 01 May 2002 Downloaded from http

Subscriber access provided by UNIV TEXAS SW MEDICAL CENTER Journal of the American Chemical Society is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Using Electrospray Ionization FTICR Mass Spectrometry To Study Competitive Binding of Inhibitors to Carbonic Anhydrase Xueheng Cheng, Ruidan Chen, James E. Bruce, Brenda L. Schwartz, Gordon A. Anderson, Steven A. Hofstadler, David C. Gale, Richard D. Smith, Jinming Gao, George B. Sigal, Mathai Mammen