Learn more about Grinnell Lab's research

Notes Synthesis of a Phosphonate Analog of Sialic Acid (Neu5Ac) Using Indium-Mediated Allylation of Unprotected Carbohydrates in Aqueous Media Jinming Gao, Valeri Martichonok, and George M. Whitesides* Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138 Received October 1, 1996 Introduction Sialic acid (Neu5Ac, 1), a constituent of sialoglycopro- teins1 and gangliosides,2 mediates a number of inter- cellular and cell-virion

Publications for Jun Yamamoto

Carbonic Anhydrase-Inhibitor Binding: From Solution to the Gas Phase Qinyuan Wu,†,§ Jinming Gao,‡ Diane Joseph-McCarthy,‡ George B. Sigal,‡ James E. Bruce,† George M. Whitesides,*,‡ and Richard D. Smith*,† EnVironmental Molecular Sciences Laboratory Pacific Northwest National Laboratory Richland, Washington 99352 Department of Chemistry and Chemical Biology HarVard UniVersity, 12 Oxford Street Cambridge, Massachusetts 02138 ReceiVed August 28, 1996 Many biochemical processes are mediated

Read the article

10 to 70% methanol in 50 mM KH2PO4 over 25 min, 10 ml/min, monitor at 380 nm). Next, the HPLC- purified mixture was desalted on the same column (methanol was removed on a rotary evaporator, and the sample loaded in H2O and eluted with 90% methanol) and lyophilized, yielding the purified Nvoc-aa-S-CoA (40 to 80% yield) as a yellow solid. For preparation of the deprotected aa-S-CoAs, the solution of Nvoc-aa-S-CoA collected from the HPLC purification was directly photolysed (4°C, 350 nm, 1 hour

Interested in our research? Get in touch to learn more or find out ways to collaborate at Yamamoto Lab.

Protein Charge Ladders, Capillary Electrophoresis, and the Role of Electrostatics in Biomolecular Recognition JEFFREY D. CARBECK, IAN J. COLTON, JINMING GAO, AND GEORGE M. WHITESIDES* Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 Received September 23, 1997 Introduction Life rests on a web of molecular recognition;1,2 the folding of proteins, the hybridization of nucleic acids, the recog- nition of signaling molecules by receptors, and the

Read about Translational CEST

Development of B-Lapachone Prodrugs forTherapyAgainst Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase1Levels Kathryn E. Reinicke,1,2 Erik A. Bey,1,3 Melissa S. Bentle,1,4 JohnJ. Pink,1,3 Stephen T. Ingalls,4,6 Charles L. Hoppel,4,6,7 Rosana I. Misico,8 GiselaM. Arzac,8 Gerardo Burton,8William G. Bornmann,9 Damon Sutton,5 Jinming Gao,5 and David A. Boothman1,3,4 Abstract B-Lapachone, an o-naphthoquinone, induces a novel caspase- and p53-independent apoptotic