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Interactions between self-assembled polyelectrolyte shells and tumor cells Hua Ai,1 John J. Pink,2 Xintao Shuai,1 David A. Boothman,2 Jinming Gao1 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 2Department of Radiation Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106 Received 23 August 2004; revised 22 November 2004; accepted 23 November 2004 Published online 1 April 2005 in

Skip to main content GEF-H1-Dependent Regulation of Anti-Tumor Immunity We discovered that intracellular activation of the GEF-H1 signaling pathway induces immune responses and dendritic cell maturation similar to microbial pattern recognition receptors. GEF-H1 directed immunity emerges as a critical mechanism that controls dendritic cell maturation upon disruption of microtubules. This immune activation pathway is induced by microtubule destabilization and controls maturation of dendritic cells

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Local release of dexamethasone from polymer millirods effectively prevents fibrosis after radiofrequency ablation Elvin Blanco,1* Brent D. Weinberg,1 Nicholas T. Stowe,2 James M. Anderson,3 Jinming Gao1* 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 3Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

The central goal of our studies is to unravel the molecular and cellular mechanisms of diseases that disrupt the motor system. In exploring these diseases, we also aim to understand a fundamental question relevant to CNS disease generally: what factors determine the selective vulnerability of

Antitumor efficacy and local distribution of doxorubicin via intratumoral delivery from polymer millirods Brent D. Weinberg,1 Hua Ai,2 Elvin Blanco,3 James M. Anderson,4 Jinming Gao3 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China 3Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 4Institute of Pathology

Skip to main content Research A Microtubule-Based Microbial Pattern Recognition System Our work has revealed polymorphisms that show that microbial defense systems could be linked to human autoimmune diseases. Find out more Development of Mucosal Immunity We study human genetic diversity associated with inflammatory bowel diseases to understand the principal mechanisms of mucosal immunity that control the intestinal barrier function and the microbiome. Find out more GEF-H1 Regulation of Anti

Seminars in Immunology xxx (xxxx) xxx Please cite this article as: Zachary T. Bennett, Seminars in Immunology, https://doi.org/10.1016/j.smim.2021.101580 1044-5323/© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Polyvalent design in the cGAS-STING pathway Zachary T. Bennett a, Suxin Li a, Baran D. Sumer b, Jinming Gao a,b,c,* a Department of Pharmacology, Harold C. Simmons

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Contents lists available at ScienceDirect Journal of Controlled Release journal homepage: www.elsevier.com/locate/jconrel Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy Min Luoa,b,1, Zhida Liua,c,1, Xinyi Zhanga, Chuanhui Hanc, Layla Z. Samandia, Chunbo Dongc, Baran D. Sumerd, Jayanthi Leae, Yang-Xin Fuc,⁎, Jinming Gaoa,⁎ a Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center