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Contact the Takahashi Lab.

Anita Dey Barsukova1 MIT Department of Mechanical Engineering, Cambridge, MA 02139 e-mail: anitadb1@mit.edu Ahmad Mujtaba Jebran1 MIT Department of Mechanical Engineering, Cambridge, MA 02139 e-mail: jebran@mit.edu Naomi Lynch MIT Department of Mechanical Engineering, Cambridge, MA 02139 e-mail: lynch.naomi@gmail.com Amit Galgali MIT Leaders for Global Operations, Cambridge, MA 02142 e-mail: amgalg@alum.mit.edu Andrea Moncada MIT Department of Mechanical Engineering, Cambridge, MA

Former Takahashi Lab members.

Ying et al., Sci. Transl. Med. 17, eadq1975 (2025) 26 February 2025 S c i e n c e T r a n s l at i o n a l M e d i c i n e | R e s e a r c h A r t i c l e 1 of 11 M E D I C A L D E V I C E S An electroadhesive hydrogel interface prolongs porcine gastrointestinal mucosal theranostics Binbin Ying1,2,3, Kewang Nan1,2,4, Qing Zhu5, Tom Khuu2, Hana Ro1, Sophia Qin3, Shubing Wang2, Karen Jiang1, Yonglin Chen2, Guangyu Bao6, Josh Jenkins1,3, Andrew Pettinari1,3, Johannes Kuosmanen1,3

About the Takahashi Lab.

Reagent/Reaction Use Ref Note DMSO/DCC (Pfitzner- Moffatt or Moffatt) Alcohol ketone/aldehyde Jacs 1963, 3027; Mech: JACS, 1965, 5561, JOC, 1967, 1926 First DMSO-based; DCC pain to remove; EDCI better DMSO/Ac2O “ Jacs 1967, 2416 DMSO/TFAA “ Jacs, 1975, 2758 DMSO/SO3-Pyridine (Parikh- Doering) “ JACS, 1967, 5505 Often under ambient conditions; best for α-chiral aldehydes/ketones (COCl)2/DMSO (swern) “ JOC, 1978, 2480; mech: Tet. 1978, 1651 Most commonly used; DMSO/Ac2O

Takahashi Lab's Other Circadian Interests 

Epoxidation, Dihydroxylation, and the Utility of Epoxides and Diols Ready Outline: Epoxidation Condensation approaches Darzens condensation Sulfur ylides With organic peroxides Peroxy acids Peroxy iminic acids Dioxiranes DMDO Enantioselective versions Metal-catalyzed Approaches V(O)(acac)2 Sharpless AE Metal Oxo’s MTO Fe, Pt and Mn-based (Salen)Mn Jacobsen AE Epoxide Ring Opening Opening under acid or basic conditions Organocopper additions Reactions of epoxy alcohols Dihydroxylation

Get to know our Principal Investigator and team of researchers at Cozen Lab.

1 R Co(CO)3(OC)3Co O O Δ (OC)3Co O R H O R H2 R H O (OC)4Co R (OC)4Co Co(CO)4 H H (CO)4CoH H2 CO R O H R CO (OC)3Co R (OC)3Co H R H2 R (OC)3Co R The Oxo process -developed in 1938 by Otto Roelen -Principle method for hydroformylation of terminal alkenes industrially -more that 4 million tons aldehyde annually -linear aldehydes more desirable Co2(CO)8 H2/CO (200-300 atm) 120-170 oC linear (normal) branched (iso) + chemical feed stocks linear alcohols