For more than eight decades, it has been known that cancer cells exhibit altered metabolism when compared to their normal counterparts

Wakeland Lab Faculty

Minireview Shape-specific polymeric nanomedicine: emerging opportunities and challenges Li Tao1, Walter Hu1, Yaling Liu2, Gang Huang3, Baran D Sumer4 and Jinming Gao3 1Erik Johnsson School of Engineering & Computer Science, University of Texas at Dallas, Richardson, TX 75080; 2Department of Mechanical Engineering and Mechanics, Lehigh University, 19 Memorial Drive West, Bethlehem, PA 18015; 3Department of Pharmacology, Harold C Simmons Comprehensive Cancer Center; 4Department of

Meet our Principal Investigator, Edward K. Wakeland, Ph.D.

Meet the PI, Berge Minassian, M.D.

Meet the Wakeland Lab alumni

Functional Nanoparticles DOI: 10.1002/anie.201100884 Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells** Kejin Zhou, Yiguang Wang, Xiaonan Huang, Katherine Luby-Phelps, Baran D. Sumer, and Jinming Gao* In recent years, multifunctional nanoparticles have received considerable attention in many applications such as biosen- sors, diagnostic nanoprobes, and targeted drug delivery.[1] These efforts have been driven to a large extent by the

ARTICLE Received 23 Jan 2015 | Accepted 1 Sep 2015 | Published 5 Oct 2015 A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles Chensu Wang1,2, Yiguang Wang1, Yang Li1, Brian Bodemann2, Tian Zhao1, Xinpeng Ma1, Gang Huang1, Zeping Hu3, Ralph J. DeBerardinis3, Michael A. White2 & Jinming Gao1 Endosomes, lysosomes and related catabolic organelles are a dynamic continuum of vacuolar structures that impact a number of cell physiological processes such as

Dynamic Article LinksC<Lab on a Chip Cite this: Lab Chip, 2011, 11, 1952 www.rsc.org/loc PAPER D ow nl oa de d by U ni ve rs ity o f T ex as a t D al la s on 0 3 Ju ly 2 01 1 Pu bl is he d on 1 9 A pr il 20 11 o n ht tp :// pu bs .r sc .o rg | do i:1 0. 10 39 /C 0L C 00 60 5J View Online Ultrasensitive protein detection using lithographically defined Si multi- nanowire field effect transistors† Ruhai Tian,ab Suresh Regonda,a Jinming Gao,b

ARTICLE Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan Chensu Wang1,2, Hanspeter Niederstrasser3, Peter M. Douglas4, Rueyling Lin4, Juan Jaramillo4, Yang Li1, Nathaniel W. Olswald3, Anwu Zhou3, Elizabeth A. McMillan2, Saurabh Mendiratta2, Zhaohui Wang1, Tian Zhao1, Zhiqaing Lin1, Min Luo1, Gang Huang1, Rolf A. Brekken1,5, Bruce A. Posner3, John B. MacMillan3, Jinming Gao1 & Michael A. White2 Drugs that mirror the cellular