Faculty Resources Employee Resources Caco-2 Permeability Caco-2 assays measure the ability of a drug to be absorbed from the gastrointestinal tract and thereby to evaluate whether the drug can be suitably dosed via an oral route. It also provides information regarding the ability of a compound to serve as a substrate for the P-glycoprotein (Pgp) efflux drug pump. Caco-2 cells are intestinal epithelial tumor cells that form a polarized monolayer, a well-defined brush border on the apical surface

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    2012;72:3038-3047. Published OnlineFirst April 24, 2012.Cancer Res   Xiumei Huang, Ying Dong, Erik A. Bey, et al.   Kills by PARP1-Induced Programmed Necrosis An NQO1 Substrate with Potent Antitumor Activity That Selectively         Updated Version 10.1158/0008-5472.CAN-11-3135doi: Access the most recent version of this article at: Material Supplementary http://cancerres.aacrjournals.org/content/suppl/2012/04/24/0008-5472.CAN-11-3135.DC1.html Access the most recent supplemental

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Meet our Principal Investigator, Emre Erol Turer, M.D., Ph.D.

Congratulations to Amit Kumar, Ph.D., lead author of the article “Molecular platform for design and synthesis of targeted dual-modality imaging probes,” published in Bioconjugate Chemistry on January 23, 2015. The article was recognized as an ACS Editors’ Choice article on February 20, 2015.

Ther Pro Poly Ying D Jer-Ts Abst Intro Pro in me dence cance therap ation treatin ternal Gy ha stages rate (2 prosta Author Oncolo 5Urolog Southw Note: S Online Y. Don Corres Stress 6001 F Phone: UTSou doi: 10 ©2010 Cance8088 Published OnlineFirst on October 12, 2010 as 10.1158/0008-5472.CAN-10-1418 Cancer esearch apeutics, Targets, and Chemical Biology state Cancer Radiosensitization through R (ADP-Ribose) Polymerase-1 Hyperactivation ong1,2, Erik A. Bey1,2, Long-Shan Li1,2

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Meet our Principal Investigator, Stephen Chung, M.D.