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Invasive Podosomes and Myoblast Fusion Elizabeth H. Chen Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA I. OVERVIEW Myoblast fusion is critical for the development, maintenance, and regeneration of skeletal muscles. Despite the identification of many fusion-related molecules in the past decades, the cellular mechanics of myoblast membrane fusion have just begun to be understood. Recent studies using the fruit fly

Article Mechanical Tension Drives Cell Membrane Fusion Graphical Abstract Highlights d Invasive protrusions trigger a mechanosensory response in a cell-fusion partner d Mechanosensory function of MyoII directs its accumulation at the fusogenic synapse d MyoII increases cortical tension and promotes fusion pore formation d Mechanical tension at the fusogenic synapse drives cell membrane fusion Kim et al., 2015, Developmental Cell 32, 561–573 March 9, 2015 ª2015 Elsevier Inc. http

JCB: Article The Rockefeller University Press $30.00 J. Cell Biol. Vol. 199 No. 1 169–185 www.jcb.org/cgi/doi/10.1083/jcb.201204065 JCB 169 R. Duan and P. Jin contributed equally to this paper. Correspondence to Elizabeth H. Chen: echen@jhmi.edu Abbreviations used in this paper: AID, auto-inhibitory domain; DPak, Drosophila p21-activated kinase; Duf, Dumbfounded; Eve, Even skipped; FCM, fusion- competent myoblast; MHC, myosin heavy chain; NPF, nucleation-promoting factor; PAK, p21-activated

Articles https://doi.org/10.1038/s41556-018-0106-3 1Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 2Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 3Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA. 4Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA. 5Departments of Biology and of Biochemistry and Molecular Biology

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Single Cell Transcriptomics – a simple walkthrough Adwait Sathe, PhD McDermott Center Bioinformatics Lab adwait.sathe@utsouthwestern.edu MCDERMOTT CENTER BIOINFORMATICS LAB 1 mailto:Adwait.sathe@utsouthwestern.edu RNASeq RNASeq 2 MCDERMOTT CENTER BIOINFORMATICS LAB https://www.10xgenomics.com/solutions/single-cell/ Single cell RNA Sequencing Workflow Dissociation of solid tissue Isolate single cells DROP-Seq, Smart-Seq etc. RNA cDNA Amplified RNA Amplified cDNA Sequencing

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