1 Ready; Catalysis Kinetics-1 There are only two important things in chemistry, kinetics and thermodynamics. And, exp(-ΔG/RT) = k1/k-1, so there’s really only one thing. Kinetics provides information about the transition state of a reaction. We’ll use a simple example to learn the basic tools, then look at more applications to catalysis. Crude Data [EtI] = [NaCN] 0 0.2 0.4 0.6 0.8 1 1.2 0 2 4 6 8 10 Time Co nc en tra tio n [EtI] [EtCN] 1st step

Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods Feng Qian, Agata Szymanski, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Received 18 August 2000; accepted 5 October 2000 Abstract: A compression–heat molding procedure was de- veloped to fabricate poly(D,L-lactide-co-glycolide) (PLGA) controlled release drug delivery devices

Ready; Catalysis Conjugate Addition Topics covered 1. 1,4 addition involving copper a. stoichiometric reactions b. catalytic reactions c. allylic substitution 2. Conjugate addition without copper a. Ni-based systems b. Rh-based systems 3. Catalytic addition of heteroatoms Topics not covered: enolate conjugate additions, Friedel-Crafts-type conjugate additions Ready; Catalysis Conjugate Addition: origin 1,4 addition reactions involving

Comparison of Doxorubicin Concentration Profiles in Radiofrequency-Ablated Rat Livers from Sustained- and Dual-Release PLGA Millirods Feng Qian,1,4 Nicholas Stowe,2 Gerald M. Saidel,1 and Jinming Gao1,3 Received November 7, 2003; accepted November 18, 2003 Purpose. To evaluate and compare the local pharmacokinetics of doxorubicin in radiofrequency (rf)-ablated rat livers after interstitial delivery from sustained- and dual-release poly(D,L-lactide-co-glyco- lide) (PLGA) millirods. Methods

Oxidation of Unsaturated Systems 2 general reactivity patterns: X H X Yn+2 X+ Yn ++ OH simple example O A- Me2SCl+ S+ O + S + Cl- 2 electron oxidation 1 electron oxidation Xor -1 e- or X we will focus on oxidation of aromatic rings and enol/enolate systems Couple Eo Fe(III) + e- Fe(II) 0.77 V(V) + e- V(IV) 1.00 Tl(III) + 2 e- Th(I) 1.25 Pb(IV) + 2 e- Pb(II) 1.6-1.7 Mn(III) + e- 1.56Mn(II) Ce(IV) + e- Ce(III) 1.6 Reduction potentials of oxidants we will look at (bigger number

www.elsevier.com/locate/jconrel Journal of Controlled Release 98 (2004) 415–426 Micellar carriers based on block copolymers of poly(q-caprolactone) and poly(ethylene glycol) for doxorubicin delivery Xintao Shuaia,1, Hua Aia,1, Norased Nasongklab, Saejeong Kima, Jinming Gaoa,* aDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA bDepartment of Macromolecular Science and Engineering, Case Western Reserve University, 10900 Euclid

Faculty Resources Employee Resources STED (access provided through the Peter O'Donnell Jr. Brain Institute) This system is owned by the Peter O'Donnell Jr. Brain Institute. The Abberior Facility Line system is a cutting-edge, high-end 3-D STED super-resolution imaging system capable of providing 40 nm isotropic resolution in samples up to 70 µm thick - xy down to 25nm. Adaptive Illumination (RESCue, DyMIN and MINFIELD) provides less phototoxicity and drastically reduces photobleaching. Adaptive

Substrate pKa's. Numbers are approximations for outside the range -2 - 16, but useful to know. For an extensive list, see http://www.chem.wisc.edu/areas/reich/pkatable/ Inorganics H2O DMSO CF3SO3H -14 HCl -8 H3O+ -2 H2O 16 NH4Cl 9 Organic X-H AcOH 5 12 O+ CH3Ph H -6 Me2OH+ -4 CH3SO3H -3 2 NH+ 5 3 N H O H 15 26 MeOH 16 28 17 29 NH3 36 38 41 EWG-CH NO2-CH3 10 17 O O 9 13 O EtO O 11 14 O EtO OEt O 13 16 O 20 27 O t-BuO 25 30 O Me2N 35 O S 3533PhOH 10 18

Meet the Napierala Lab

1 Ready; Catalysis Organometallics: Definitions Organometallics: Hard to define usefully and completely at the same time, but generally: Compounds containing metal-carbon bond(s). Fe Cl Ti Cl Cl ClFe NC NC CN CN CN CN K3 No question: Organometallic No question: Inorganic ???? Catalysis further complicates the issue: CH3 Br CH3 (HO)2B H3C + Me2N PCy2 PdL L H3C CH3 CH3 CH3 CH3 CH3 2% Pd(OAc)2 3% L CsF, rt L = Buchwald, JACS, 1998, 9722