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The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.

EDITORIAL Theranostic nanomedicine for cancer Baran Sumer1, Jinming Gao2† †Author for correspondence 1Department of Otolaryngology, Head and Neck Surgery, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA Tel.: +1 214 648 3102; Fax: +1 214 648 2246; E-mail: baran.sumer@ utsouthwestern.edu 2Department of Pharmacology, Harold C Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75093

Subscriber access provided by UNIV TEXAS SW MEDICAL CENTER Journal of the American Chemical Society is published by the American Chemical Society. 1155 Sixteenth Street N.W., Washington, DC 20036 Using Electrospray Ionization FTICR Mass Spectrometry To Study Competitive Binding of Inhibitors to Carbonic Anhydrase Xueheng Cheng, Ruidan Chen, James E. Bruce, Brenda L. Schwartz, Gordon A. Anderson, Steven A. Hofstadler, David C. Gale, Richard D. Smith, Jinming Gao, George B. Sigal, Mathai Mammen

Cytochrome P450 Inhibition Currently under Redevelopment Because of the important role of Cytochrome p450 enzymes in drug metabolism, it is important to assess the ability of lead compounds to inhibit specific cytochrome p450 enzymes to avoid potential drug-drug interactions where one drug may affect the metabolism of another. This assay is only recommended for advanced leads. Typical Assay Conditions Isoform Source Substrate Positive Inhibitor 1A2 BD Bioscience Supersome phenacetin furfylline

Zinc ferrite nanoparticles as MRI contrast agentsw Carlos Bárcena, a Amandeep K. Sra, a Girija S. Chaubey, b Chalermchai Khemtong, a J. Ping Liu b and Jinming Gao* a Received (in Cambridge, UK) 21st January 2008, Accepted 15th February 2008 First published as an Advance Article on the web 11th March 2008 DOI: 10.1039/b801041b Mixed spinel hydrophobic ZnxFe1�xO�Fe2O3 (up to x = 0.34) nanoparticles encapsulated in polymeric micelles exhibited in- creased T2 relaxivity and sensitivity

NATURE BIOMEDICAL ENGINEERING 1, 0006 (2016) | DOI: 10.1038/s41551-016-0006 | www.nature.com/natbiomedeng 1 ARTICLES PUBLISHED: 19 DECEMBER 2016 | VOLUME: 1 | ARTICLE NUMBER: 0006 A transistor-like pH nanoprobe for tumour detection and image-guided surgery Tian Zhao1​†, Gang Huang1, Yang Li1, Shunchun Yang1, Saleh Ramezani2, Zhiqiang Lin1, Yiguang Wang1, Xinpeng Ma1, Zhiqun Zeng1, Min Luo1, Esther de Boer3, Xian-Jin Xie4, Joel Thibodeaux5, Rolf A. Brekken6, Xiankai Sun2, Baran D. Sumer7

The Institutional Review Board is primarily concerned with ensuring that the rights, welfare, and privacy of human research participants are protected.

Intratumoral Delivery of B-Lapachone via Polymer Implants for Prostate Cancer Therapy Ying Dong,1Shook-Fong Chin,1Elvin Blanco,1Erik A. Bey,1Wareef Kabbani,2 Xian-Jin Xie,1,3 William G. Bornmann,4 David A. Boothman,1andJinming Gao1 Abstract Purpose: h-Lapachone (ARQ 501, a formulation of h-lapachone complexed with hydroxy- propyl-h-cyclodextrin) is a novel anticancer agent with selectivity against prostate cancer cells overexpressing theNAD(P)H:quinone oxidoreductase-1enzyme. Lackof solubility

J O U R N A L O F M A T E R I A L S S C I E N C E 3 9 (2 0 0 4 ) 1429 – 1432 Size-controlled polyelectrolyte nanocapsules via layer-by-layer self-assembly H. AI , J . GAO Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 E-mail: jinming@cwru.edu Nanomaterials have found many important applica- tions in biomedical, pharmaceutical, electronic, and molecular diagnostic fields. The recent introduction of electrostatic layer-by-layer (LbL) self-assembly