ARTICLE Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window Xu Wang 1, Jonathan Wilhelm 1, Wei Li1, Suxin Li1, Zhaohui Wang1, Gang Huang1, Jian Wang1, Houliang Tang1, Sina Khorsandi 2, Zhichen Sun 1, Bret Evers 3 & Jinming Gao 1✉ Stimuli-sensitive nanomaterials with cooperative response are capable of converting subtle and gradual biological variations into robust outputs to improve the precision of diagnostic or therapeutic outcomes. In this study, we report the

Publications Archive for James A. Richardson D.V.M., Ph.D., Diplomate (ACVP) Wiseman D, Hanzlik JA, Richardson JA, Shelton JM, Evers BM, Diamond MP, Brown R, Mazzucco DC. "Development of a Chronic Canine Ovariohysterectomy Model to Evaluate Vaginal Cuff Healing Using Two Closure Systems." Surg Innov. 2022 April 18;29(2):183-194. Luitel, K., Kim, S.B., Barron, S., Richardson, J.A., Shay, J.W. "Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention

ARTICLE Received 23 May 2016 | Accepted 13 Sep 2016 | Published 27 Oct 2016 Molecular basis of cooperativity in pH-triggered supramolecular self-assembly Yang Li1, Tian Zhao1, Chensu Wang1,2, Zhiqiang Lin1, Gang Huang1, Baran D. Sumer3 & Jinming Gao1 Supramolecular self-assembly offers a powerful strategy to produce high-performance, stimuli-responsive nanomaterials. However, lack of molecular understanding of stimulated responses frequently hampers our ability to rationally design

Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions Xinpeng Ma,†,‡ Yiguang Wang,†,‡ Tian Zhao,† Yang Li,† Lee-Chun Su,† Zhaohui Wang,† Gang Huang,† Baran D. Sumer,§ and Jinming Gao*,†,∥ †Department of Pharmacology and §Department of Otolaryngology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States ∥Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75083, United

\ PEGSITACIANINE FOR THE SURGICAL DETECTION OF HEAD AND NECK CANCER PURPOSE INCLUSION DESIGN To investigate whether Pegsitacianine a fluorescent nanoparticle can image head and neck cancer and unknown primary head and neck cancer during surgery or biopsy. 1. Adults ≥ 18 years of age 2. Patients with stage 1-4 Head and Neck Squamous Cell Carcinoma (HNSCC) undergoing surgical excision 1. Phase 2 Clinical trial of Pegsitacianine, which is

CELL SCIENCE AT A GLANCE The fusogenic synapse at a glance Ji Hoon Kim1 and Elizabeth H. Chen2,3,* ABSTRACT Cell–cell fusion is a fundamental process underlying fertilization, development, regeneration and physiology of metazoans. It is a multi-step process involving cell recognition and adhesion, actin cytoskeletal rearrangements, fusogen engagement, lipid mixing and fusion pore formation, ultimately resulting in the integration of two fusion partners. Here, we focus on the asymmetric actin

ARTICLES PUBLISHED ONLINE: 8 DECEMBER 2013 | DOI: 10.1038/NMAT3819 A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals Yiguang Wang1, Kejin Zhou1, Gang Huang1, Christopher Hensley2, Xiaonan Huang1, Xinpeng Ma1, Tian Zhao1, Baran D. Sumer3, Ralph J. DeBerardinis2 and Jinming Gao1* Stimuli-responsive nanomaterials are increasingly important in a variety of applications such as biosensing, molecular imaging, drug

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Unveiling the Mechanisms of Cell-Cell Fusion Elizabeth H. Chen1* and Eric N. Olson2* Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-cell fusion are also required for seemingly unrelated cellular processes such as phagocytosis, cell migration, axon growth, and synaptogenesis. We review advances in understanding cell-cell fusion by

Mechanisms of myoblast fusion during muscle development Ji Hoon Kim1, Peng Jin1, Rui Duan1, and Elizabeth H. Chen1,2 1Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 Abstract The development and regeneration of skeletal muscles require the fusion of mononulceated muscle cells to form multinucleated, contractile muscle fibers. Studies using a simple genetic model, Drosophila melanogaster, have discovered many evolutionarily