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ARTICLE Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery F. J. Voskuil 1,13, P. J. Steinkamp 2,13, T. Zhao3, B. van der Vegt 4, M. Koller2, J. J. Doff4, Y. Jayalakshmi3, J. P. Hartung5, J. Gao 6,7, B. D. Sumer 6✉, M. J. H. Witjes1, G. M. van Dam 2,8✉ & the SHINE study group* Cancer cell metabolism leads to a uniquely acidic microenvironment in solid tumors, but exploiting the labile extracellular pH differences

Ready; Catalysis Conjugate Addition Topics covered 1. 1,4 addition involving copper a. stoichiometric reactions b. catalytic reactions c. allylic substitution 2. Conjugate addition without copper a. Ni-based systems b. Rh-based systems 3. Catalytic addition of heteroatoms Topics not covered: enolate conjugate additions, Friedel-Crafts-type conjugate additions Ready; Catalysis Conjugate Addition: origin 1,4 addition reactions involving

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Oxidation of Unsaturated Systems 2 general reactivity patterns: X H X Yn+2 X+ Yn ++ OH simple example O A- Me2SCl+ S+ O + S + Cl- 2 electron oxidation 1 electron oxidation Xor -1 e- or X we will focus on oxidation of aromatic rings and enol/enolate systems Couple Eo Fe(III) + e- Fe(II) 0.77 V(V) + e- V(IV) 1.00 Tl(III) + 2 e- Th(I) 1.25 Pb(IV) + 2 e- Pb(II) 1.6-1.7 Mn(III) + e- 1.56Mn(II) Ce(IV) + e- Ce(III) 1.6 Reduction potentials of oxidants we will look at (bigger number

Chen (Zhijian "James") Lab publications

Skip to main content Positions Postdoctoral Fellows To inquire about a position, please email Dr. Ni with a current CV, a 1-page description of your research interests, and contact information for three professional references. Information on our postdoctoral training program and benefits can be found through UTSW's Graduate School of Biomedical Sciences. Graduate Students We accept Ph.D. students through UT Southwestern's Graduate School of Biomedical Sciences . Prospective rotation students

Skip to main content Search Labs A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z Lab Name or Principal Investigator Centers/Institutes Advanced Imaging Research Center Cecil H. and Ida Green Center for Reproductive Biology Sciences Center for Alzheimer's and Neurodegenerative Diseases Center for Hypothalamic Research Center for Organogenesis Research and Trauma Center for the Genetics of Host Defense Charles and Jane Pak Center for Mineral

Skip to main content People Josephine Ni, M.D. Assistant Professor Department of Internal Medicine Department of Microbiology As a physician-scientist, Dr. Ni explores bacterial colonization of the healthy and inflamed intestinal tract with the goal of modulating the gut microbiota to treat intestinal diseases. Dr. Ni graduated from the University of California, Berkeley, and earned her medical degree at Northwestern University. She completed a residency in internal medicine at New York

Minimal Residual Disease and Metastasis Postdoctoral positions are available in the laboratory of Dr. Srinivas Malladi, Ph.D. - Faculty Profile - UT Southwestern, Department of Pathology at UT Southwestern Medical Center to study the biology of minimal residual disease and metastasis in breast, lung and renal Adenocarcinomas. Malladi Lab - UT Southwestern, Dallas, Texas is focused on understanding how disseminated cancer cells survive, evade immune surveillance and give rise to overt

Skip to main content Publications for Josephine Ni, M.D. Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD, Gastroenterology 2021 Nov Risk for Post-Colonoscopy Irritable Bowel Syndrome in