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1Scientific RePorTS | (2018) 8:4501 | DOI:10.1038/s41598-018-22819-3 www.nature.com/scientificreports Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation Antoine Abou-Jaoude1, Lise Badiqué1, Mohamed Mlih1, Sara Awan1, Sunning Guo1, Alexandre Lemle1, Clauda Abboud1, Sophie Foppolo1, Lionel Host1, Jérôme Terrand1, Hélène Justiniano1, Joachim Herz2, Rachel L. Matz1 & Philippe Boucher   1

Advanced Synthesis and Catalysis, 2006 Unless noted, class is 9:00-10:30, mon and wed, L4.14 Date Topic Lecturer 8-22 Intro to catalysis Ready 8-24 Organometallics: structure/reactivity-1 Ready 8-29 Organometallics: structure/reactivity-2 Ready 8-31 Kinetics and mech-1 Ready 9-5 Kinetics and mech-2 Ready 9-7 Kinetic resolutions Ready 9-12 Nonlinear effects Ready 9-14 Addns to pi bonds-1 Ready 9-19 Addns to pi bonds-2 Ready 9-21 Addns to pi bonds-3 Ready 9-26 Conjugate addition-1 Ready 9-28

1 updated May 2025 Napierala Lab protocol for culturing human iPSCs For additional details and recommendations, please refer to “Maintenance of Human Pluripotent Stem Cells in mTeSRTM Plus” Technical Manual (STEMCELL Technologies). Necessary Reagents Reagent Company Catalog Number Corning™ Matrigel™ hESC-Qualified Matrix Fisher Scientific 08-774-552 mTeSRTM Plus Complete Kit STEMCELL Technologies 100-0276 CryoStor® CS10 STEMCELL Technologies 07930 Dispase 1U/mL, 100mL

Protecting Groups in Organic Synthesis-1 Ready Protecting groups are a sad fact of synthetic chemistry They are usually needed, but rarely desired Many syntheses have stalled because of trouble putting on or removing protecting groups 4 basic questions to address when choosing a P.G.: 1. Can I put it on where and only where I want? 2. Can I take it and only it off? 3. Will it survive all future reaction conditions? 4. Will it

1 updated May 2025 Sendai virus reprogrammed iPSC Lines * Clone used for CRISPR/Cas9 editing of GAA repeats Line Clone # Sex GAA repeat number in fibroblasts GAA repeat number in iPSCs Karyotype data Karyotype passage CTRL 3348 6 M Control size Control size Yes, normal p11 CTRL 7522 5 F Control size Control size Yes, normal p15 CTRL 7522 12 F Control size Control size Yes, normal p13 CTRL 6718 1 M Control size Control size Yes, normal p4 CTRL 6718 6 M

Ready; Catalysis Isomerization/cyclization-1 R M R' M R R' H R R' M H MH R R' H R' M M H Olefin insertion into Metal alkyl can be followed by hydride elimination or additional olefin insertions: -dimerization/oligomerization -small molecules -polymerization Recall: electron rich M (late transition metal) Keq < 1 ->dimerization, etc electron poor M (early transition metal) Keq > 1 ->polymerization P Ph2 Ni OO H C7-C14 C1-C3 HO C10-C18 C1-C3 C7-C14 Shell

Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial adhesion and lesion macrophage accumulation Yinyuan Ding1,2,3,*, Linzhang Huang4,*, Xunde Xian1,2,*, Ivan S. Yuhanna4, Catherine R. Wasser1,2, Michael Frotscher5, Chieko Mineo4, Philip W. Shaul4,†, and Joachim Herz1,2,6,7,8,† 1Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390, USA. 2Center for Translational Neurodegeneration Research, UT Southwestern Medical Center, Dallas

1 R Co(CO)3(OC)3Co O O Δ (OC)3Co O R H O R H2 R H O (OC)4Co R (OC)4Co Co(CO)4 H H (CO)4CoH H2 CO R O H R CO (OC)3Co R (OC)3Co H R H2 R (OC)3Co R The Oxo process -developed in 1938 by Otto Roelen -Principle method for hydroformylation of terminal alkenes industrially -more that 4 million tons aldehyde annually -linear aldehydes more desirable Co2(CO)8 H2/CO (200-300 atm) 120-170 oC linear (normal) branched (iso) + chemical feed stocks linear alcohols

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning Catherine R. Wasser1,2,*,>†, Irene Masiulis2,†, Murat S. Durakoglugil1,2, Courtney Lane- Donovan1,2, Xunde Xian1,2, Uwe Beffert2, Anandita Agarwala2, Robert E. Hammer3, and Joachim Herz1,2,4,5,* 1Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA 2Department of Molecular Genetics, University of Texas Southwestern Medical