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1 Ready; Catalysis Organometallics: Definitions Organometallics: Hard to define usefully and completely at the same time, but generally: Compounds containing metal-carbon bond(s). Fe Cl Ti Cl Cl ClFe NC NC CN CN CN CN K3 No question: Organometallic No question: Inorganic ???? Catalysis further complicates the issue: CH3 Br CH3 (HO)2B H3C + Me2N PCy2 PdL L H3C CH3 CH3 CH3 CH3 CH3 2% Pd(OAc)2 3% L CsF, rt L = Buchwald, JACS, 1998, 9722

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1 Kinetic Resolutions Material outline: For the Scientist in you: Definitions Theoretical treatment For the technician in you: Practical considerations Useful KR’s Oxidative KR of allylic alcohols An extreme example Acylation/deacylation Hydrogenation olefins ketones Dynamic kinetic resolution Epoxide ring opening A very extreme example Parallel kinetic resolution General References: Vedejs, ACIEE, 2005, 3974 Jacobsen, Adv. Syn

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CANCER RESEARCH | MOLECULAR CELL BIOLOGY HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis Yanling Niu1, Lei Bao1, Yan Chen1, ChenliangWang1, Maowu Luo1, Bo Zhang1, Mi Zhou1, Jennifer E. Wang1, Yisheng V. Fang1, Ashwani Kumar2, Chao Xing2,3,4, Yingfei Wang1,5, and Weibo Luo1,6 ABSTRACT ◥ Hypoxia induces a vast array of long noncoding RNAs (lncRNA) in breast cancer cells, but their biological functions remain largely unknown. Here

Engelking Lab Publications

Received May 10, 2020, accepted May 24, 2020. Date of publication xxxx 00, 0000, date of current version xxxx 00, 0000. Digital Object Identifier 10.1109/ACCESS.2020.2999079 Mining Domain Knowledge: Improved Framework Towards Automatically Standardizing Anatomical Structure Nomenclature in Radiotherapy QIMING YANG 1,2, HONGYANG CHAO 1,2, (Member, IEEE), DAN NGUYEN1, AND STEVE JIANG1 1Medical Artificial Intelligence and Automation Laboratory, Department of Radiation Oncology, University of

Cooperativity Principles in Self-Assembled Nanomedicine Yang Li,† Yiguang Wang,†,‡ Gang Huang,† and Jinming Gao*,† †Department of Pharmacology, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, United States ‡Beijing Key Laboratory of Molecular Pharmaceutics and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China ABSTRACT: Nanomedicine is a discipline that applies nanoscience and

Nano-Immune-Engineering Approaches to Advance Cancer Immunotherapy: Lessons from Ultra-pH-Sensitive Nanoparticles Published as part of the Accounts of Chemical Research special issue “Chemistry in Cancer Immunotheranostics”. Suxin Li, Zachary T. Bennett, Baran D. Sumer, and Jinming Gao* Cite This: Acc. Chem. Res. 2020, 53, 2546−2557 Read Online ACCESS Metrics & More Article Recommendations CONSPECTUS: Immunotherapy has transformed the field of oncology and patient care. By leveraging the

We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.