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Skip to main content Microbial Transcriptional Regulators Control Mucosal Host Defenses We demonstrated that Interferon regulatory factor (IRF)1 is a component of cyclic dinucleotide recognition that allows mucosal DCs to induce host defense through TH1 7 cells and shape protective immune responses in the intestine to cope with entero-invasive pathogens such as S. typhimurium. We identified IRF1 as a pivotal transcription factor in the Sensor Stimulator of Interferon Genes (STING) nucleotide

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Skip to main content Research A Microtubule-Based Microbial Pattern Recognition System Our work has revealed polymorphisms that show that microbial defense systems could be linked to human autoimmune diseases. Find out more Development of Mucosal Immunity We study human genetic diversity associated with inflammatory bowel diseases to understand the principal mechanisms of mucosal immunity that control the intestinal barrier function and the microbiome. Find out more GEF-H1 Regulation of Anti

Skip to main content Development of Mucosal Immunity We study human genetic diversity associated with inflammatory bowel diseases to understand the principal mechanisms of mucosal immunity that control the intestinal barrier function and the microbiome. Immune responses control host defenses intestinal at epithelial interphases.

Skip to main content GEF-H1-Dependent Regulation of Anti-Tumor Immunity We discovered that intracellular activation of the GEF-H1 signaling pathway induces immune responses and dendritic cell maturation similar to microbial pattern recognition receptors. GEF-H1 directed immunity emerges as a critical mechanism that controls dendritic cell maturation upon disruption of microtubules. This immune activation pathway is induced by microtubule destabilization and controls maturation of dendritic cells

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Skip to main content People Josephine Ni, M.D. Assistant Professor Department of Internal Medicine Department of Microbiology As a physician-scientist, Dr. Ni explores bacterial colonization of the healthy and inflamed intestinal tract with the goal of modulating the gut microbiota to treat intestinal diseases. Dr. Ni graduated from the University of California, Berkeley, and earned her medical degree at Northwestern University. She completed a residency in internal medicine at New York

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Skip to main content Publications for Josephine Ni, M.D. Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD, Gastroenterology 2021 Nov Risk for Post-Colonoscopy Irritable Bowel Syndrome in