1Scientific RePoRTS | (2018) 8:4501 | DOI:10.1038/s41598-018-22819-3 www.nature.com/scientificreports Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation Antoine Abou-Jaoude1, Lise Badiqué1, Mohamed Mlih1, Sara Awan1, Sunning Guo1, Alexandre Lemle1, Clauda Abboud1, Sophie Foppolo1, Lionel Host1, Jérôme Terrand1, Hélène Justiniano1, Joachim Herz2, Rachel L. Matz1 & Philippe Boucher 1

Postdoctoral Training in Gene Regulation Molecular Mechanisms, Genomics, Mouse Models, Translational/Clinical A postdoctoral training position is available in the laboratory of Dr. Cristel Camacho, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to study gene regulation in breast cancer. The Camacho Lab has several exciting projects related to hormone signaling and gene regulation, focusing on transcription and nuclear endpoints

Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial adhesion and lesion macrophage accumulation Yinyuan Ding1,2,3,*, Linzhang Huang4,*, Xunde Xian1,2,*, Ivan S. Yuhanna4, Catherine R. Wasser1,2, Michael Frotscher5, Chieko Mineo4, Philip W. Shaul4,†, and Joachim Herz1,2,6,7,8,† 1Department of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390, USA. 2Center for Translational Neurodegeneration Research, UT Southwestern Medical Center, Dallas

Department of Radiation Oncology 2280 Inwood Road, Dallas, Texas 75390-9303 Phone: 214-645-8525 Fax: 214-645-8526 utsouthwestern.edu Postdoctoral Fellow in Biomedical Optics and Medical Physics We are seeking skilled and enthusiastic candidates for Postdoctoral Fellow positions in the Biomedical Imaging and Radiation Technology Laboratory (BIRTLab). Our mission is to innovate, develop, and apply cutting- edge biomedical technology to empower cancer

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning Catherine R. Wasser1,2,*,>†, Irene Masiulis2,†, Murat S. Durakoglugil1,2, Courtney Lane- Donovan1,2, Xunde Xian1,2, Uwe Beffert2, Anandita Agarwala2, Robert E. Hammer3, and Joachim Herz1,2,4,5,* 1Center for Translational Neurodegeneration Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA 2Department of Molecular Genetics, University of Texas Southwestern Medical

1 P(tBu)2 P(tBu)2 CuBr P Pd P P P PBu3 Pt H Et3P Cl PEt3 Ir S R3P H PR3 H S -S PF6 - Ir S R3P H PR3 H P P Pd PF6 - Pt H Et3P Cl PEt3 Py P P Ir S R3P H PR3 H PF6 - Pt H Et3P Py PEt3 Cl Fe Pt H Et3P Py PEt3 P P Cl- Organometallic Reaction Mechanisms Ligand association/dissociation + toluene insoluble (PBu3)nCuBr soluble + active catalyst for cross coupling = NOTE: No ox. state change Ligand Exchange: Associative - common for 16e- complexes

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. A Rohlmann, … , R E Hammer, J Herz J Clin Invest. 1998;101(3):689-695. https://doi.org/10.1172/JCI1240. The multifunctional low density lipoprotein (LDL) receptor-related protein (LRP) has been postulated to participate in a number of diverse physiological and pathological processes ranging from the homeostasis of plasma lipoproteins, atherosclerosis, and

We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.

Moral Reasoning in Scientific Research Cases for Teaching and Assessment Developed by Muriel J. Bebeau, University of Minnesota with Kenneth D. Pimple, Karen M. T. Muskavitch, Sandra L. Borden, and David H. Smith, Indiana University December 1995 These materials were developed for a project entitled “Teaching Research Ethics: A Workshop at Indiana University” (TRE). Funding was provided by the United States Department of Education’s Fund for the Improvement of Postsecondary Education

#!/usr/bin/perl     open(FILE1,  "Input.fastq")  or  die("Unable  to  open  file");   open(OUTPUT,  ">Output.fastq")  or  die("Unable  to  open  file");   use  strict;     my  $line;   my  @line;   my  $line1;   my  $seq0;   my  $junk;   my  $qual0;   my  $qual;   my  $seq;   my  $base;   my  $rest;   my  $newline;   my  @newline;   my  $n=1;   my  $m=1;   my  $newscore;   my  $restscore;   my