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Comparison of Doxorubicin Concentration Profiles in Radiofrequency-Ablated Rat Livers from Sustained- and Dual-Release PLGA Millirods Feng Qian,1,4 Nicholas Stowe,2 Gerald M. Saidel,1 and Jinming Gao1,3 Received November 7, 2003; accepted November 18, 2003 Purpose. To evaluate and compare the local pharmacokinetics of doxorubicin in radiofrequency (rf)-ablated rat livers after interstitial delivery from sustained- and dual-release poly(D,L-lactide-co-glyco- lide) (PLGA) millirods. Methods

©2 005 LA ND ES BIO SCI EN CE. DO NO T D IST RIB UT E. [Cancer Biology & Therapy 4:1, 95-102, January 2005]; ©2005 Landes Bioscience Matthew Ough4 Anne Lewis4 Erik A. Bey6 Jinming Gao6 Justine M. Ritchie3 William Bornmann7 David A. Boothman6 Larry W. Oberley2,3,4 Joseph J. Cullen1,2,3,4,5,* Departments of 1Surgery, 2Radiation Oncology and the 3Holden Comprehensive Cancer Center; 4University of Iowa College of Medicine; Iowa City, Iowa USA 5Veterans Affairs Medical Center; Iowa

Enhancement of Solubility and Bioavailability of �-Lapachone Using Cyclodextrin Inclusion Complexes Norased Nasongkla,1,2 Andy F. Wiedmann,2 Andrew Bruening,3 Meghan Beman,3 Dale Ray,4 William G. Bornmann,5 David A. Boothman,3 and Jinming Gao2,6 Received June 11, 2003; Accepted June 19, 2003 Purpose. To explore the use of cyclodextrins (CD) to form inclusion complexes with �-lapachone (�-lap) to overcome solubility and bio- availability problems previously noted with this drug. Methods

Local carboplatin delivery and tissue distribution in livers after radiofrequency ablation A. Szymanski-Exner,1 A. Gallacher,2 N. T. Stowe,3 B. Weinberg,1 J. R. Haaga,4 J. Gao1,4 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 2Department of Analytical Chemistry, Ricerca, LLC, Concord, Ohio 3Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 4Department of Radiology, University Hospitals of

Bioorganic Chemistry cRGD-Functionalized Polymer Micelles for Targeted Doxorubicin Delivery** Norased Nasongkla, Xintao Shuai, Hua Ai, Brent D. Weinberg, John Pink, David A. Boothman, and Jinming Gao* Low water solubility, rapid phagocytic and renal clearance, and systemic toxicity represent three major barriers that limit the therapeutic use of many hydrophobic antitumor agents such as doxorubicin (DOXO) and paclitaxel.[1] Various drug- delivery systems, among which polymeric micelles have

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Local release of dexamethasone from polymer millirods effectively prevents fibrosis after radiofrequency ablation Elvin Blanco,1* Brent D. Weinberg,1 Nicholas T. Stowe,2 James M. Anderson,3 Jinming Gao1* 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 3Institute of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106

Poly(D, L-lactide-co-glycolide)/Poly(ethylenimine) Blend Matrix System for pH Sensitive Drug Delivery Damon Sutton, Remy Durand, Xintao Shuai,† Jinming Gao* Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 Received 29 April 2005; accepted 14 July 2005 DOI 10.1002/app.22636 Published online 9 January 2006 in Wiley InterScience (www.interscience.wiley.com). ABSTRACT: Poly(d,l-lactide-co-glycolide) (PLGA) and poly(ethylenimine) (PEI) were blended and

2021 Publications Li J, Canseco D, Wang Y, Vale G, Chaudhary J, Anwar A, Baniasadi H, Williams NS , Gopal P, Sutphin PD, McDonald JG, Putnam WC, Corbin IR. Assessing the safety of transarterial locoregional delivery of low-density lipoprotein docosahexaenoic acid nanoparticles to the rat liver. Eur J Pharm Biopharm . 2021 Jan;158:273-283. PMCID: PMC8121338. Marcyk PT, LeBlanc EV, Kuntz DA, Xue A, Ortiz F , Trilles R, Bengtson S, Kenney TMG, Huang DS, Robbins N, Williams NS , Krysan DJ, Privé GG

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by �-lapachone Erik A. Bey†‡§, Melissa S. Bentle¶, Kathryn E. Reinicke�, Ying Dong†‡, Chin-Rang Yang‡, Luc Girard††, John D. Minna††, William G. Bornmann‡‡, Jinming Gao‡, and David A. Boothman†‡§ †Departments of Pharmacology and Oncology, Laboratory of Molecular Stress Responses, ‡Program in Cell Stress and Cancer Nanomedicine, Simmons Comprehensive Cancer Center, and ††Hamon Center for Therapeutic