Feasibility assessments help determine the ability to recruit your population of interest from UT Southwestern patients as you develop a study.

Genetics, Single-Cell Sequencing, and RNA Sequencing Core Provides exome sequencing and gene expression and analysis. Program Director Jonathan Cohen, Ph.D. Professor Center for Human Nutrition jonathan.cohen@UTSouthwestern.edu Phone: 214-648-4774 Back-to top

Pilot and Feasibility Program Awardees 2024 Pilot & Feasibility Grant Awardees Amanda Casey, Ph.D. Assistant Professor Renewal The Role of Fic-mediated AMPylation in Metabolic Disease Dr. Casey will study the role of cell stress pathways in cells that regulate metabolism during the course of diet-induced obesity. She will use a novel genetically modified mouse model to investigate the role of cell stress in several key tissues regulating blood glucose levels and whole-body metabolism

Animal Phenotyping/Metabolism Core Example of one of our services we offer to our NORC investigators on a Seahorse instrument Mitochondrial Respiratory Profile. Oxygen-consumption in live-cells in response to basal conditions (glucose and pyruvate), oligomycin (ATP synthase inhibitor), FCCP (chemical uncoupler), and antimycin-A (complex III inhibitor). The Metabolic Phenotyping Core (MPC) provides state-of-the-art analytical and phenotypical measures to the scientific community both inside and

Julie Mirpuri, M.D., stands beside her likeness at #IfThenSheCan – The Exhibit at the Smithsonian in Washington, D.C. The UTSW faculty member’s statue is one of 120 of female innovators in medicine, science, and other fields that is part of an initiative to inspire girls to pursue STEMM careers. DALLAS – Mar. 25, 2022 – Julie Mirpuri, M.D. , Associate Professor of Pediatrics and a neonatologist, felt humbled to see a life-size neon orange replica of herself among the 120 statues of diverse

(Photo Credit: Getty Images) DALLAS – Oct. 25, 2023 – Patients with endometriosis are more likely to experience complications during and after hysterectomies, a study by UT Southwestern Medical Center researchers shows. The findings, published in the Journal of Minimally Invasive Gynecology , suggest surgeons should be prepared for the problems that may occur in patients with endometriosis, a painful condition that affects about 15% of women and is a major cause of infertility. “This study

Formulation It is frequently necessary for most hydrophobic small molecules to develop a specific formulation that will allow in vivo delivery of the compound at suitable concentrations. The Pharmacology Core makes use of a simple decision tree published some years ago by scientists at Pfizer for development of solution formulations for IV and IP dosing (1). This method gradually tests solubility of the compound in aqueous buffers, with changes in pH as appropriate to the compound’s pka, then

Directory Jay Horton, M.D. Managing Director Project: Administrative Core UTSWNORC@UTSouthwestern.edu Joel Elmquist, D.V.M., Ph.D. Director Pilot & Feasibility Core Joel.Elmquist@UTSouthwestern.edu Joyce Repa, PhD Co-Director Pilot & Feasibility Core Joyce.Repa@UTSouthwestern.edu Jeffrey Zigman, M.D., Ph.D. Director Enrichment Program Jeffrey.Zigman@UTSouthwestern.edu Philipp Scherer, Ph.D. Director Animal Phenotyping Core Philipp.Scherer@UTSouthwestern.edu Jeffrey McDonald, Ph.D. Director Lipid

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