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Publications Huang, W.; Li, H.; Kiselar, J.; Fink, S. P.; Regmi, S.; Day, A.; Yuan, Y.; Chance, M.; Ready, J. M.; Markowitz, S. D.; Taylor, D. J. Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system . Nature Commun . 2023, 14. Imlay, L. S.; Lawong, A. K.; Gahalawat, S.; Kumar, A.; Xing, C.; Mittal, N.; Wittlin, S.; Churchyard, A.; Niederstrasser, H.; Crespo-Fernandez, B.; Posner, B. A.; Gamo, F.-J.; Baum, J.; Winzeler, E. A.; Laleu, B.; Ready, J. M.; Phillips, M

Patents Issued Patents Markowitz, S.; Ho, W. J.; Yuan, Y.; Jain, M.; Sabeh, M.; Ready, J.; Williams, N. Inhibitors of short-chain dehydrogenase activity for treating coronary disorders. 2022, US 11,426,420 B2. Word, R. A.; Annavarapu, H. K.; Posner, B.; Ready, J.; Markowitz, S. Compositions and methods for modulating cervical ripening. 2019, WO 2019010482. Markowitz, S.; Antczak, M.; Ready, J.; Zhang, Y. Preparation of thienopyridines and related compounds, their compositions and methods of

Past Winners Inaugural Prize Winner, 2023 UT Southwestern Medical Center presented the inaugural Beth Levine, M.D. Prize in Autophagy Research to Japanese biochemist and molecular biologist Noboru Mizushima, M.D., Ph.D. “Autophagy represents a fundamental cellular process with immense implications for human health and disease. Our research not only deepens our understanding of the underlying molecular mechanisms but also opens up new possibilities for developing targeted therapies that harness

UT Southwestern Medical Center established this international prize in her honor, recognizing that very few U.S. medical schools act as the sponsoring organization for prizes in any field of medicine. The Beth Levine, M.D. Prize in Autophagy Research is only the sixth example of a prize being

Contact Us The Histo Pathology Core is a fully-staffed service center offering research histology and anatomic pathology on a fee-for-service basis. The lab is directed by Pathologist Bret Evers M.D., Ph.D., and is staffed with full-time research technicians and assistants. The lab continues to collaborate with Veterinary Pathologist and Professor Emeritus James Richardson, D.V.M., Ph.D, as well as as previous lab manager and veteran molecular histologist, John Shelton. General Contact Info

Microscopy & Rulers Users of the Histo Pathology Core's services are welcome to use the Core's Microscopy Facilities. Email the Core Operations Manager to be added to the Microscope Users Group. Once added to the user group, you will have access to the Core's Imaging Calendar through Outlook. Instructions for the Core's Compound Microscope, as well as the camera systems, can be downloaded at the following link: Jenoptik Gryphax Camera System Users of the Histo Pathology Core's Client Microscopy

Billing & Fees The Histo Pathology Core's fee schedule and menu of special stains are provided to assist with budgeting and for reconciling invoices. Menu of Special Stains For clients of the Histo Pathology Core that are internal to UT Southwestern Medical Center, payment of monthly invoices is handled by debiting of chart of accounts on file via Interface IDR in Oracle PeopleSoft. Notice of a coming PeopleSoft IDR is emailed to PI and Admin of Record a few days prior to allow for chart of

The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.

The Electron Microscopy Core Facility (EMCF) offers TEM of cells & tissues, negative staining, whole-mount SEM, correlative LM and EM, and Immunogold labeling.

The UT Southwestern High-Throughput Screening Core works collaboratively with principal investigators on both chemical and genome-wide siRNA Screens.