The Mission of MBR is to provide access to state-of-the-art biophysical instrumentation, experimental design, and analyses to the UTSW community. MBR seeks to accomplish this goal by maintaining a wide variety of such instrumentation and training users regarding its proper operation. Further, users

Publications 2023 Brautigam, C.A. (2023). SViMULATE: a computer program facilitating the interactive, multi-mode simulation of analytical ultracentrifugation data. Eur. Biophys. J. , 52, 293-302. 2022 Tso, S.C., Jowitt, T.A., & Brautigam, C.A. (2022). The feasibility of determining kinetic constants from isothermal titration calorimetry data. Biophysical J. , 121, 2474-2484. 2021 Tso, S.C. & Brautigam, C.A. (2021). Measuring the KD of protein-protein interactions using microscale thermophoresis

MBR Services have experienced practitioners of the biophysical methods. They can design, execute, and analyze biophysical experiments with macromolecules that you supply. This approach can be useful when time to complete an experiment is short or when no lab personnel are available to undergo

Sequencing Our facility is equipped with one Illumina NextSeq 2000, three NextSeq 500s, and one Miseq System. The NextSeq 2000 offers three flowcells: Flowcell # of reads Read Lengths P1 100 M 300 Cycles P2 400 M 100, 200 and 300 Cycles P3 1.2 B 50, 100, 200 and 300 Cycles The NextSeq 500 offers 5 flowcells: Flowcell # of reads Kit Capacity 75 High Output 400 M 75 Cycles 150 Mid Output 130 M 150 Cycles 150 High Output 400 M 150 Cycles 300 Mid Output 130 M 300 Cycles 300 High Output 400 M 300

The intent of the pilot program is to attract strong applications from new investigators with novel scientific studies to established investigators that are in pursuit of a new research direction that involves inter-institutional and interdisciplinary concepts.

Prices and other charges for various services provided by the Microbiome Research Lab at UT Southwestern.

Photo Gallery Click image to view full version - Rendering of frontal mouse brain section Mouse brain; frontal sectioning. 3-color dataset was acquired on Zeiss LSM980 with AiryScan2 and AI sample finder; Objective: Plan-Apochromat 25x/0.8 oil immersion. Top: Overview. Right side: raw data, Middle: raw data + overlay; Left: overlay - Imaris spot detection for red/blue channels and surface detection for green channel. Bottom: zoom-in. Image properties: 735 stitched tiles; pixel size: 0.124 x

Helpful documents and instructions for working with the Nuclear Magnetic Resonance Core facility at UT Southwestern.

The Biochemistry NMR Core is a 24/7, open access facility where, after receiving the required training, users generally operate the instruments themselves and run their own samples. However, services are also available to UTSW internal users who prefer to have their samples run for them by facility

Publications Recent publications (core staff in bold) Wang W, Ranjan A, Zhang W, Liang Q, MacMillan KS, Chapman K, Wang X , Chandrasekaran P, Williams NS , Rosenbaum DM, De Brabander JK. Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines. Bioorg Med Chem Lett . 2024 Feb 1; 99 : 129624 . PubMed PMID: 38272190 . Prakasam G, Mishra A, Christie A, Miyata J, Carrillo D, Tcheuyap VT, Ye H, Do QN, Wang Y, Reig Torras O, Butti R, Zhong H, Gagan J, Jones KB