Search

The UT Southwestern Genomics Core provides access to next generation sequencing to investigators at UT Southwestern and other institutions.

The UT Southwestern High-Throughput Screening Core works collaboratively with principal investigators on both chemical and genome-wide siRNA Screens.

Check out the latest information on the Translational Molecular Imaging Core (TMIC) Core.

Whole Brain Microscopy Equipment The WBMF offers access to a unique set of high-throughput microscopes and histology resources, ideal for collecting high-content neuroscience data, for UT Southwestern and external researchers. Please remember to acknowledge your usage of our facility resources in your publications using our established Research Resource Identifier code anywhere in your methods or acknowledgements: RRID: SCR_017949 . This is critical for us to maintain support for the core. Jump

Whole Brain Microscopy Services & Fees 3D Volumetric Imaging and Automated Analysis We can generate high-resolution, whole-brain/whole-tissue 3D images as a full-service operation using serial two-photon tomography (STPT) or lightsheet microscopy according to specific experimental needs. Fixed specimens can be provided to the core, and we can take it from there. Core staff can perform STPT or tissue clearing using the Clear+ method, whole-brain/whole-tissue immunostaining, and lightsheet

These are the pubished works during 2020-present by researchers in the Structural Biology Laboratory at UT Southwestern.

Structural Biology Lab provides helpful resources such as protocols for equipement setup and use, protein handling tips, and videos.

Equipment in the Structural Biology Lab of Core Facilities includes robotic crystal sample handling, automatic plunge freezing, crystallization tray setup, X-ray generators, cryo-electron microscopes, and high-resolution SEM coating systems.

Photo Gallery Click image to view full version Yet another failed cell division HeLa cells plated in a glass-bottom dish were imaged for 36 hrs on the Tomocube HT-X1 Plus. A sub-stack of brightfield images shows another failed division of a multinucleated HeLa cell. Imaged by Marcel Mettlen. Fiji-based image segmentation Cells were stained for plasma membrane (CDH5/VE-cadherin, magenta), Golgi (red), actin (green), and nuclei (blue). Imaged on a Nikon CSU-W1 spinning disk confocal microscope

Publications Recent publications (core staff in bold) Wang W, Ranjan A, Zhang W, Liang Q, MacMillan KS, Chapman K, Wang X , Chandrasekaran P, Williams NS , Rosenbaum DM, De Brabander JK. Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines. Bioorg Med Chem Lett . 2024 Feb 1; 99 : 129624 . PubMed PMID: 38272190 . Prakasam G, Mishra A, Christie A, Miyata J, Carrillo D, Tcheuyap VT, Ye H, Do QN, Wang Y, Reig Torras O, Butti R, Zhong H, Gagan J, Jones KB