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A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn’t receive this treatment, UT Southwestern researchers report in a new study.

Nitrous oxide, a commonly used analgesic gas, improved temporary opening of the blood-brain barrier (BBB) and gene therapy delivery in mouse models using focused ultrasound (FUS), UT Southwestern Medical Center researchers report in a new study.

Seemingly healthy people whose blood contained antibodies associated with a condition called antiphospholipid syndrome (APS) were significantly more likely to experience a cardiovascular event such as a heart attack or stroke than those without, a study led by UT Southwestern scientists shows.

Black and Hispanic children with high-risk neuroblastoma experience worse survival outcomes than their white peers, even when treated in frontline clinical trials, according to a study led by a UT Southwestern Medical Center researcher.

Fat cells genetically altered to overproduce a hormone called FGF21 resulted in improved metabolic health and an extended lifespan in mice that were fed a high-fat diet, UT Southwestern Medical Center researchers report. The findings, published in Cell Metabolism, could lead to new interventions

An artificial intelligence (AI)-based model developed by UT Southwestern Medical Center researchers can accurately predict which kidney cancer patients will benefit from anti-angiogenic therapy, a class of treatments that’s only effective in some cases.

Patients with sickle cell disease (SCD) who undergo total knee replacement are at higher risk for complications than non-SCD patients, according to a large-scale, retrospective study by researchers from UT Southwestern Medical Center and the University of Calgary.

Loss of a gene known as SYNCRIP in prostate cancer tumors unleashes cellular machinery that creates random mutations throughout the genome that drive resistance to targeted treatments, a team led by UT Southwestern Medical Center researchers discovered.

A well-known class of drugs used to manage Type 2 diabetes and control weight could offer hope for patients who also struggle with related chronic kidney disease (CKD), researchers at UT Southwestern Medical Center found.

Multidrug resistance in cancer can be overcome by combining a drug that blocks a key enzyme with another anticancer drug, according to a study in preclinical models led by researchers at UT Southwestern Medical Center. The findings, published in Science Advances, could have implications for patients