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Enhancement of Solubility and Bioavailability of �-Lapachone Using Cyclodextrin Inclusion Complexes Norased Nasongkla,1,2 Andy F. Wiedmann,2 Andrew Bruening,3 Meghan Beman,3 Dale Ray,4 William G. Bornmann,5 David A. Boothman,3 and Jinming Gao2,6 Received June 11, 2003; Accepted June 19, 2003 Purpose. To explore the use of cyclodextrins (CD) to form inclusion complexes with �-lapachone (�-lap) to overcome solubility and bio- availability problems previously noted with this drug. Methods

Skip to main content New Drugs for Lung Cancer Treatment Discovery of New Drugs for the Treatment of Lung Cancer The objective of this Cancer Prevention and Research Institute of Texas (CPRIT) project is to identify and target lung cancer acquired vulnerabilities (“synthetic lethalities”) that have arisen during lung cancer pathogenesis and that can be used as new, cancer specific therapeutic targets with associated molecular “enrollment biomarkers” for personalized treatment. When oncogenic

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Skip to main content Cleveland Clinic Research Highlight Cleveland Clinic highlighted our recently published Nature paper in the following article Cleveland Clinic Lerner Research Institute News . This is a brief overview of what our current goals are, and if you are further interested in our research please feel free to reach out.

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Publications by Xiaosong Meng, PI of the Meng Lab at UT Southwestern.

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We have shown the A51R gene family to encode a group of highly conserved, microtubule-stabilizing virulence factors that, remarkably, promote virus replication in both Lepidopteran and vertebrate hosts. We are actively investigating how these fascinating proteins inhibit antiviral defenses in such