The Osborne Lab focuses on how regulation of miRNA and mRNA control the branching of developing cells and how disregulation of these pathways contributes to aggressive tumor behavior, especially chemoresistance and metastasis.

Towards a molecular pathway for myoblast fusion in Drosophila Elizabeth H. Chen1,2 and Eric N. Olson1 1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA 2Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA Intercellular fusion among myoblasts is required for the generation of multinucleated muscle fibers during

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O'Donnell Lab Photo Gallery 2012-16

CELL SCIENCE AT A GLANCE The fusogenic synapse at a glance Ji Hoon Kim1 and Elizabeth H. Chen2,3,* ABSTRACT Cell–cell fusion is a fundamental process underlying fertilization, development, regeneration and physiology of metazoans. It is a multi-step process involving cell recognition and adhesion, actin cytoskeletal rearrangements, fusogen engagement, lipid mixing and fusion pore formation, ultimately resulting in the integration of two fusion partners. Here, we focus on the asymmetric actin