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Developmental Cell, Vol. 1, 705–715, November, 2001, Copyright 2001 by Cell Press Antisocial, an Intracellular Adaptor Protein, Is Required for Myoblast Fusion in Drosophila founder cells while the remaining twist-expressing cells become fusion competent (for reviews, see Baylies et al., 1998; Frasch, 1999). It is believed that the founder Elizabeth H. Chen and Eric N. Olson1 Department of Molecular Biology University of Texas Southwestern Medical Center at Dallas cells serve as sources of

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| PERSPECTIVES Sex and the Single Fly: A Perspective on the Career of Bruce S. Baker Deborah J. Andrew,* Elizabeth H. Chen,†,‡,§ Devanand S. Manoli,**,†† Lisa C. Ryner,‡‡ and Michelle N. Arbeitman§§,1 *Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, †Department of Molecular Biology, ‡Department of Cell Biology, §and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390

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People & Ideas JCB • VOLUME 206 • NUMBER 5 • 2014576 M ost cells in the body are solo entities, self-contained within a cell membrane. But there are certain cases in which cells meld together. Skeletal muscle cells, for example, are multinucleate syncytia that form through the process of cell–cell fusion. Osteo- clasts, a type of cell involved in bone remodeling, also fuse together to promote better bone resorption. And you would not be reading this article were it not for a

The Osborne Lab is looking for postdocs, grad students, and tech staff with expertise in cell biology, biochemistry, and molecular biology, who will make a difference in understanding and treating cancer.

Requirement of the fusogenic micropeptide myomixer for muscle formation in zebrafish Jun Shia,b,1, Pengpeng Bia,b,c,1, Jimin Peid, Hui Lia,b,c, Nick V. Grishind,e, Rhonda Bassel-Dubya,b,c, Elizabeth H. Chena,b,2, and Eric N. Olsona,b,c,2 aDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390; bHamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; cSenator Paul D. Wellstone Muscular

The Osborne Lab is looking for postdocs, grad students, and tech staff with expertise in cell biology, biochemistry, and molecular biology, who will make a difference in understanding and treating cancer.

Unveiling the Mechanisms of Cell-Cell Fusion Elizabeth H. Chen1* and Eric N. Olson2* Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-cell fusion are also required for seemingly unrelated cellular processes such as phagocytosis, cell migration, axon growth, and synaptogenesis. We review advances in understanding cell-cell fusion by