Where does the secreted protein acidic and rich in cysteine (SPARC) protein originate? What leads to its expression? SPARC is secreted from cells. Virtually any cell can produce SPARC. In fact most cells that are adherent in tissue culture produce SPARC at a detectable level. Growth of cells in culture is stressful and SPARC is a protein that is often produced by cells under stress, thus the concept of it as a ‘culture shock’ protein was established. In tissues, cells that are

Protein Charge Ladders, Capillary Electrophoresis, and the Role of Electrostatics in Biomolecular Recognition JEFFREY D. CARBECK, IAN J. COLTON, JINMING GAO, AND GEORGE M. WHITESIDES* Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 Received September 23, 1997 Introduction Life rests on a web of molecular recognition;1,2 the folding of proteins, the hybridization of nucleic acids, the recog- nition of signaling molecules by receptors, and the

Department of Radiation Oncology 2280 Inwood Road, Dallas, Texas 75390-9303 Phone: 214-645-8525 Fax: 214-645-8526 utsouthwestern.edu Postdoctoral Fellow in Biomedical Optics and Medical Physics We are seeking skilled and enthusiastic candidates for Postdoctoral Fellow positions in the Biomedical Imaging and Radiation Technology Laboratory (BIRTLab). Our mission is to innovate, develop, and apply cutting- edge biomedical technology to empower cancer

10 to 70% methanol in 50 mM KH2PO4 over 25 min, 10 ml/min, monitor at 380 nm). Next, the HPLC- purified mixture was desalted on the same column (methanol was removed on a rotary evaporator, and the sample loaded in H2O and eluted with 90% methanol) and lyophilized, yielding the purified Nvoc-aa-S-CoA (40 to 80% yield) as a yellow solid. For preparation of the deprotected aa-S-CoAs, the solution of Nvoc-aa-S-CoA collected from the HPLC purification was directly photolysed (4°C, 350 nm, 1 hour

Membrane-encased polymer millirods for sustained release of 5-fluorouracil Feng Qian, Norased Nasongkla, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Received 10 November 2001; revised 26 November 2001; accepted 26 November 2001 Abstract: This article describes the design and develop- ment of a novel membrane-encased polymer millirod for the sustained release of an

COMMUNICATION www.advhealthmat.de Tumor-Targeted Inhibition of Monocarboxylate Transporter  Improves T-Cell Immunotherapy of Solid Tumors Tongyi Huang, Qiang Feng, Zhaohui Wang, Wei Li, Zhichen Sun, Jonathan Wilhelm, Gang Huang, Tram Vo, Baran D. Sumer, and Jinming Gao* Export of lactic acid from glycolytic cancer cells to the extracellular tumor milieu has been reported to enhance tumor growth and suppress antitumor immunity

1310 IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 21, NO. 10, OCTOBER 2002 X-Ray Computed Tomography Methods forIn Vivo Evaluation of Local Drug Release Systems Kyle A. Salem, Student Member, IEEE, Agata Szymanski-Exner, Roee S. Lazebnik, Michael S. Breen, Jinming Gao, and David L. Wilson�, Member, IEEE Abstract—Recent advances in drug delivery techniques have necessitated the development of tools forin vivomonitoring of drug distributions. Gamma emission imaging and magnetic resonance imaging

Cooperativity Principles in Self-Assembled Nanomedicine Yang Li,† Yiguang Wang,†,‡ Gang Huang,† and Jinming Gao*,† †Department of Pharmacology, Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, United States ‡Beijing Key Laboratory of Molecular Pharmaceutics and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, China ABSTRACT: Nanomedicine is a discipline that applies nanoscience and

Postdoctoral Position in Neuroimaging A postdoctoral training position is available in the BioMedical Imaging Research Lab (BiMIR) led by Dr. Jiaen Liu in the Advanced Imaging Research Center (AIRC) at UT Southwestern Medical Center to develop advanced high resolution MRI methods for neuroimaging applications. BiMIR has several exciting projects related to novel MRI acquisition and reconstruction, ultrahigh-field MRI (≥7 T), quantitative MRI (T2, T2* and MT) for myelin and iron