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ARTICLE Received 23 May 2016 | Accepted 13 Sep 2016 | Published 27 Oct 2016 Molecular basis of cooperativity in pH-triggered supramolecular self-assembly Yang Li1, Tian Zhao1, Chensu Wang1,2, Zhiqiang Lin1, Gang Huang1, Baran D. Sumer3 & Jinming Gao1 Supramolecular self-assembly offers a powerful strategy to produce high-performance, stimuli-responsive nanomaterials. However, lack of molecular understanding of stimulated responses frequently hampers our ability to rationally design

Kidney Practice Practical Questions: 1. Bowman's space 2. Bowman's capsule 3. Parietal epithelial cell 4. Mesangial cell 5. Glomerular capillary 6. Urinary pole 7. Vascular pole 8. Cell that senses filtrate osmolarity 9. Cell that produces renin 10. Nucleus of a proximal convoluted epithelial cell 11. Nucleus of a proximal straight epithelial cell 12. Nucleus of a loop of Henle epithelial cell 13. Nucleus of a distal straight epithelial cell 14. Nucleus of a distal convoluted

ARTICLE Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window Xu Wang 1, Jonathan Wilhelm 1, Wei Li1, Suxin Li1, Zhaohui Wang1, Gang Huang1, Jian Wang1, Houliang Tang1, Sina Khorsandi 2, Zhichen Sun 1, Bret Evers 3 & Jinming Gao 1✉ Stimuli-sensitive nanomaterials with cooperative response are capable of converting subtle and gradual biological variations into robust outputs to improve the precision of diagnostic or therapeutic outcomes. In this study, we report the

ARTICLE OPEN Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling Alexander Bartelt1,2,8, Friederike Behler-Janbeck1,2, F. Timo Beil1,3, Till Koehne3,4, Brigitte Müller1,2, Tobias Schmidt1,2, Markus Heine2,5, Laura Ochs1,2, Tayfun Yilmaz3, Martin Dietrich6, Jan P. Tuckermann7, Michael Amling3, Joachim Herz6, Thorsten Schinke3, Joerg Heeren2 and Andreas Niemeier1,2 Skeletal health relies on architectural integrity and sufficient

Single Cell Transcriptomics – a simple walkthrough Adwait Sathe, PhD McDermott Center Bioinformatics Lab adwait.sathe@utsouthwestern.edu MCDERMOTT CENTER BIOINFORMATICS LAB 1 mailto:Adwait.sathe@utsouthwestern.edu RNASeq RNASeq 2 MCDERMOTT CENTER BIOINFORMATICS LAB https://www.10xgenomics.com/solutions/single-cell/ Single cell RNA Sequencing Workflow Dissociation of solid tissue Isolate single cells DROP-Seq, Smart-Seq etc. RNA cDNA Amplified RNA Amplified cDNA Sequencing

Didactic Answers 1. Epimysium surrounds A. skeletal muscle fibers B. cardiomyocytes C. smooth muscle cells D. skeletal muscle fascicles E. skeletal muscles 2. Perimysium surrounds A. skeletal muscle fibers B. cardiomyocytes C. smooth muscle cells D. skeletal muscle fascicles E. skeletal muscles 3. Endomysium surrounds A. skeletal muscle fibers B. cardiomyocytes C. smooth muscle cells D. skeletal muscle fascicles E. skeletal muscles 4. Fascicles are A. groupings of

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The Science Teacher46 For the past six summers, the Northwest Association for Biomedical Re- search (NWABR) has provided an in-depth weeklong professional development program for teachers titled “Ethics in the Science Classroom.” This program, funded by a Science Education Partnership Award from the National Center for Research Resources at the National Institutes of Health, has provided nearly 150 teachers with background in ethical reasoning and science content related to controversial

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Harold C. Simmons Comprehensive Cancer Center Bioinformatics Data Science Shared Resource Data Science Collaboration Agreement SCCC-DSSR This agreement is between the DSSR user named below and the Director of SCCC-DSSR, Professor Jeon Lee. By signing this document, user acknowledges and agrees to the conditions listed below. DSSR collaborator (Full Name