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Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release Chao Kong,† Yang Li,‡ Zhengsheng Liu,† Junxiao Ye,† Zhaohui Wang,‡ Ling Zhang,† Weijian Kong,† Huiqin Liu,† Chun Liu,† Huanhuan Pang,§ Zeping Hu,§ Jinming Gao,*,‡ and Feng Qian*,† †School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education

Get to know our Principal Investigator and team of researchers at Xie (Xiao-Song) Lab

We are interested in the function of chromatin regulation of signaling pathways important for neural development, brain tumor growth and autism pathogenesis.

ARTICLE Received 23 Jan 2015 | Accepted 1 Sep 2015 | Published 5 Oct 2015 A nanobuffer reporter library for fine-scale imaging and perturbation of endocytic organelles Chensu Wang1,2, Yiguang Wang1, Yang Li1, Brian Bodemann2, Tian Zhao1, Xinpeng Ma1, Gang Huang1, Zeping Hu3, Ralph J. DeBerardinis3, Michael A. White2 & Jinming Gao1 Endosomes, lysosomes and related catabolic organelles are a dynamic continuum of vacuolar structures that impact a number of cell physiological processes such as

Skip to main content EVEXIA Mood Disorders Research Our research-driven self-monitoring tool for mental wellness Self-monitoring involves keeping a personal record of your moods and behaviors in order to track trends over time. This allows individuals to observe how their mental state changes and provides concrete data to show how they are progressing, and which symptom profiles need attention. Self-monitoring for Mental Health What is self-monitoring? Tracking trends to inform decision-making

ARTICLE Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan Chensu Wang1,2, Hanspeter Niederstrasser3, Peter M. Douglas4, Rueyling Lin4, Juan Jaramillo4, Yang Li1, Nathaniel W. Olswald3, Anwu Zhou3, Elizabeth A. McMillan2, Saurabh Mendiratta2, Zhaohui Wang1, Tian Zhao1, Zhiqaing Lin1, Min Luo1, Gang Huang1, Rolf A. Brekken1,5, Bruce A. Posner3, John B. MacMillan3, Jinming Gao1 & Michael A. White2 Drugs that mirror the cellular

Skip to main content Texas-Resilience Against Depression Program Mood Disorders Research Developing a Biosignature for Depression The Texas-Resilience Against Depression (T-RAD) program collects genetic, clinical, demographic, behavioral, and biological information from individuals at risk and those who have been diagnosed with depression or bipolar disorder. Through this 10-year program of 5,000 people, we hope to determine how best to treat and reduce the risk of mood disorders. Not all

Trivedi Lab's Cloudbreak Initiative

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Meet the Mootha Lab team.