628 graft morphology and function have not been adequately addressed. A systematic understanding of the effects of in vitro parameters will be important if these culture tech- niques are to be translated to human cells for the develop- ment of autologous human vascular grafts that have acceptable long-term function in vivo.7 A large array of parameters has an impact on the devel- opment of engineered tissues, including cell sourcing, bioreactor design, nutrient medium composition, growth

Get to know our Principal Investigator and team of researchers at Helen Yin Lab.

Fabrication and characterization of controlled release poly(D,L-lactide-co-glycolide) millirods Feng Qian, Agata Szymanski, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 Received 18 August 2000; accepted 5 October 2000 Abstract: A compression–heat molding procedure was de- veloped to fabricate poly(D,L-lactide-co-glycolide) (PLGA) controlled release drug delivery devices

We focus on the lipid kinases that synthesize PIP2 (phosphatidylinositol phosphate 5 kinases, PIP5Ks) and PI4P (phosphatidylinositol 4 kinases, PI4Ks), as well as the regulatory proteins that respond to PIP2 and PI4P. 

Journal of Controlled Release 83 (2002) 415–425 www.elsevier.com/ locate/ jconrel N oninvasive monitoring of local drug release in a rabbit radiofrequency (RF) ablation model using X-ray computed tomography a b a aAgata Szymanski-Exner , Nicholas T. Stowe , Roee S. Lazebnik , Kyle Salem , a c a,c ,*David L. Wilson , John R. Haaga , Jinming Gao aDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106,USA bDepartment of Surgery, Case Western Reserve

Herz Lab publications

In vivo drug distribution dynamics in thermoablated and normal rabbit livers from biodegradable polymers Jinming Gao,1 Feng Qian,1 Agata Szymanski-Exner,1 Nicholas Stowe,2 John Haaga3 1Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Department of Surgery, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 3Department of Radiology, University Hospitals of Cleveland, Cleveland, Ohio

Meet our Principal Investigator, Stephen Chung, M.D.

Comparison of Doxorubicin Concentration Profiles in Radiofrequency-Ablated Rat Livers from Sustained- and Dual-Release PLGA Millirods Feng Qian,1,4 Nicholas Stowe,2 Gerald M. Saidel,1 and Jinming Gao1,3 Received November 7, 2003; accepted November 18, 2003 Purpose. To evaluate and compare the local pharmacokinetics of doxorubicin in radiofrequency (rf)-ablated rat livers after interstitial delivery from sustained- and dual-release poly(D,L-lactide-co-glyco- lide) (PLGA) millirods. Methods

Meet the PI, Berge Minassian, M.D.