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We are interested in building small organic molecules and studying their functions in biological systems. Our lab started in 2004 using state-of-the-art tools to address challenging issues in the field of natural product synthesis. 

There are at least two distinct circadian timekeeping mechanisms in the central nervous system of mammals, the light-entrainable oscillator (LEO) in the suprachiasmatic nucleus (SCN) and the food-entrainable oscillator (FEO), which controls food anticipatory activity.

Skip to main content Research Why are eating disorders important to study? Eating disorders (EDs) are complex mental illnesses that afflict nearly 5% of the population. While they are most common in women between the ages of 12-35, EDs can affect people of any age and gender and emerge in response to biological, psychological, and social factors. Anorexia nervosa (AN) has a mortality rate of 5-10%, the highest of any psychiatric disorder. AN affects nearly 1% of young women. Bulimia nervosa (BN

Publications for Yamazaki Lab

Guanosine tetra- and penta-phosphate–collectively known as (p)ppGpp–was discovered in the 1960s as a secondary messenger that signals starvation in bacteria.

Ufret-Vincenty Lab publications

Site-specific functionalization of proteins in vivo lays the fundamental of of numerous powerful chemical biology tools to elucidate protein functions.

Grinnell Teaching Awards

Meet the PI, V. Vinod Mootha, M.D.

Learn about Grinnell Lab's science