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http://www.tandfonline.com/idrt ISSN: 1061-186X (print), 1029-2330 (electronic) J Drug Target, 2015; 23(7–8): 672–680 ! 2015 Taylor & Francis. DOI: 10.3109/1061186X.2015.1073296 REVIEW ARTICLE Nanotechnology-enabled delivery of NQO1 bioactivatable drugs Xinpeng Ma*y, Zachary R. Moore*, Gang Huang, Xiumei Huang, David A. Boothman, and Jinming Gao Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA Abstract

Yamazaki Lab research focuses on two main approaches: Using Period knockout mice to understand circadian timekeeping and photo/food entrainment Understanding the mechanisms that connect and disconnect the circadian rhythm and cell cycle

Site-specific functionalization of proteins in vivo lays the fundamental of of numerous powerful chemical biology tools to elucidate protein functions.

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Critical ReviewsTM in Eukaryotic Gene Expression, 24(1):15-28 (2014) 151045-4403/14/$35.00 © 2014 Begell House, Inc. www.begellhouse.com Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other Diseases Julio C. Morales,1 Longshan Li,1 Farjana J. Fattah,1 Ying Dong,1 Erik A. Bey,2 Malina Patel,1 Jinming Gao,1 & David A. Boothman1* 1Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75399; 2Department

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Guanosine tetra- and penta-phosphate–collectively known as (p)ppGpp–was discovered in the 1960s as a secondary messenger that signals starvation in bacteria.