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Get to know our Principal Investigator and team of researchers at Helen Yin Lab.

Ultra-pH-Sensitive Nanoprobe Library with Broad pH Tunability and Fluorescence Emissions Xinpeng Ma,†,‡ Yiguang Wang,†,‡ Tian Zhao,† Yang Li,† Lee-Chun Su,† Zhaohui Wang,† Gang Huang,† Baran D. Sumer,§ and Jinming Gao*,†,∥ †Department of Pharmacology and §Department of Otolaryngology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States ∥Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75083, United

We have found that PI4P is essential for recruitment of adaptor coat proteins to the Golgi and propose that PI4P helps establish the Golgi's unique organelle identify.

Articles https://doi.org/10.1038/s41551-020-00675-9 1Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. 2Department of Pathology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. 3Department of Otolaryngology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. 4Howard Hughes

We now want to know how gelsolin and gelsolin-like proteins behave in living cells. We are developing a fluorescence energy transfer reporter to monitor gelsolin activation in live cells.

ARTICLE Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window Xu Wang 1, Jonathan Wilhelm 1, Wei Li1, Suxin Li1, Zhaohui Wang1, Gang Huang1, Jian Wang1, Houliang Tang1, Sina Khorsandi 2, Zhichen Sun 1, Bret Evers 3 & Jinming Gao 1✉ Stimuli-sensitive nanomaterials with cooperative response are capable of converting subtle and gradual biological variations into robust outputs to improve the precision of diagnostic or therapeutic outcomes. In this study, we report the

Learn about the Michaely Lab's research.

COMMUNICATION www.advhealthmat.de Tumor-Targeted Inhibition of Monocarboxylate Transporter  Improves T-Cell Immunotherapy of Solid Tumors Tongyi Huang, Qiang Feng, Zhaohui Wang, Wei Li, Zhichen Sun, Jonathan Wilhelm, Gang Huang, Tram Vo, Baran D. Sumer, and Jinming Gao* Export of lactic acid from glycolytic cancer cells to the extracellular tumor milieu has been reported to enhance tumor growth and suppress antitumor immunity

Contact the Michaely Lab.

Zhongzheng (Brooks) Fu, Ph.D. Last updated: September, 2023 ORCID: 0000-0002-2572-6284 Email: zhongzheng.fu@utsouthwestern.edu Website: zfu-lab.org 5323 Harry Hines Blvd, MC 8855 Dallas, TX 75390 United States Academic Positions 2023 – on Assistant Professor Department of Neurological Surgery UT Southwestern Medical Center Dallas, TX, USA 2023 – on Visiting Scholar Division of the Humanities and Social Sciences California Institute of Technology Pasadena, CA, USA Postdoctoral Trainings