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Cell, Vol. 114, 751–762, September 19, 2003, Copyright 2003 by Cell Press Control of Myoblast Fusion by a Guanine Nucleotide Exchange Factor, Loner, and Its Effector ARF6 regulators of myoblast fusion identified genetically in Drosophila are likely to provide insights into mammalian myogenesis, as well as intercellular fusion in general. The somatic musculature of the Drosophila embryo is derived from the embryonic mesoderm. During mid- Elizabeth H. Chen, Brian A. Pryce, Jarvis A. Tzeng

Napierala Lab FRDA Families

Developmental Cell, Vol. 1, 705–715, November, 2001, Copyright 2001 by Cell Press Antisocial, an Intracellular Adaptor Protein, Is Required for Myoblast Fusion in Drosophila founder cells while the remaining twist-expressing cells become fusion competent (for reviews, see Baylies et al., 1998; Frasch, 1999). It is believed that the founder Elizabeth H. Chen and Eric N. Olson1 Department of Molecular Biology University of Texas Southwestern Medical Center at Dallas cells serve as sources of

Learn about the Chung Lab's research

Competition between Blown Fuse and WASP for WIP binding regulates the dynamics of WASP-dependent actin polymerization in vivo Peng Jin1,*, Rui Duan1,*, Fengbao Luo1, Guofeng Zhang2, Sabrina N. Hong1, and Elizabeth H. Chen1,3 1 Dept. of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2 Laboratory of Bioengineering and Physical Science, National Institute of Biomedical Imaging and Bioengineering, National Institute of Health, Bethesda, MD

Learn about the Minassian Lab's research.

JCB: Article The Rockefeller University Press   $30.00 J. Cell Biol. Vol. 199 No. 1  169–185 www.jcb.org/cgi/doi/10.1083/jcb.201204065 JCB 169 R. Duan and P. Jin contributed equally to this paper. Correspondence to Elizabeth H. Chen: echen@jhmi.edu Abbreviations used in this paper: AID, auto-inhibitory domain; DPak, Drosophila p21-activated kinase; Duf, Dumbfounded; Eve, Even skipped; FCM, fusion- competent myoblast; MHC, myosin heavy chain; NPF, nucleation-promoting factor; PAK, p21

Meet our Principal Investigator, Stephen Chung, M.D.