ARTICLE Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery F. J. Voskuil 1,13, P. J. Steinkamp 2,13, T. Zhao3, B. van der Vegt 4, M. Koller2, J. J. Doff4, Y. Jayalakshmi3, J. P. Hartung5, J. Gao 6,7, B. D. Sumer 6✉, M. J. H. Witjes1, G. M. van Dam 2,8✉ & the SHINE study group* Cancer cell metabolism leads to a uniquely acidic microenvironment in solid tumors, but exploiting the labile extracellular pH differences

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Skip to main content Opportunities We're looking for: Graduate student or Postdoctoral scholar to study TAO protein kinase structures and their nuclear interactions with phosphatases. TAOs can influence the Hippo pathway, influence neuronal development, and survival of certain parasites and viral infections and yet qualify as understudied protein kinases. Postdoctoral scholar to coordinate studies on WNK protein kinases and biological evaluation of inhibitors. Please send a cover letter and CV

Grinnell Lab's Bioethics for HS Students

The application of Focused Ultrasound (FUS) coupled with IV administration of microbubbles is a unique method whereby localized opening of the BBB can be achieved in a non-invasive manner.

North Texas Bioethics Network

The research focus in the Corbin lab investigates strategies that exploits the deviant metabolism of cancer cells (namely the reprogramming of lipid metabolism and altered redox biology) for therapeutic purposes.

Grinnell  Videos

Lipoproteins are naturally occurring core-shell nanostructures, ranging from 7nm to over a micron inn size, they serve as the main transport vehicles for cholesterol and triacylglycerol in mammalian systems

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