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Join us at the Chung Lab

Skip to main content Microbial Transcriptional Regulators Control Mucosal Host Defenses We demonstrated that Interferon regulatory factor (IRF)1 is a component of cyclic dinucleotide recognition that allows mucosal DCs to induce host defense through TH1 7 cells and shape protective immune responses in the intestine to cope with entero-invasive pathogens such as S. typhimurium. We identified IRF1 as a pivotal transcription factor in the Sensor Stimulator of Interferon Genes (STING) nucleotide

Meet the PI, Berge Minassian, M.D.

Skip to main content GEF-H1-Dependent Regulation of Anti-Tumor Immunity We discovered that intracellular activation of the GEF-H1 signaling pathway induces immune responses and dendritic cell maturation similar to microbial pattern recognition receptors. GEF-H1 directed immunity emerges as a critical mechanism that controls dendritic cell maturation upon disruption of microtubules. This immune activation pathway is induced by microtubule destabilization and controls maturation of dendritic cells

Meet our Principal Investigator, Stephen Chung, M.D.

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Skip to main content Join Us Become a Team Member The Whitehurst lab is seeking energetic, dedicated graduate students and postdoctoral fellows to join our work. Current Projects Cancer-Testis Antigens (aka Cancer Germline Genes) Cancer-testis antigens are normally only expressed in testis, but we have discovered a cohort of cancer-testis antigens expressed in tumor cells and localized to the mitochondria. Inhibition of these proteins leads to a loss of tumor cell viability. This project will