Search

L E C T U R E S E R I E S CARDIOMETABOLIC Dr. Vaduganathan received his medical degree from Northwestern University, where he also obtained a master’s degree of public health. He completed residency training at Massachusetts General Hospital and fellowship training in cardiovascular medicine at Brigham and Women’s Hospital. His research is centered on drug development, clinical trials, and the implementation of cardio-renal-metabolic therapies. Dr. Vaduganathan has authored or co-authored

Postdoctoral Training in Gene Regulation Molecular Mechanisms, Genomics, Mouse Models, Translational/Clinical A postdoctoral training position is available in the laboratory of Dr. Cristel Camacho, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to study gene regulation in breast cancer. The Camacho Lab has several exciting projects related to hormone signaling and gene regulation, focusing on transcription and nuclear endpoints

Department of Radiation Oncology 2280 Inwood Road, Dallas, Texas 75390-9303 Phone: 214-645-8525 Fax: 214-645-8526 utsouthwestern.edu Postdoctoral Fellow in Biomedical Optics and Medical Physics We are seeking skilled and enthusiastic candidates for Postdoctoral Fellow positions in the Biomedical Imaging and Radiation Technology Laboratory (BIRTLab). Our mission is to innovate, develop, and apply cutting- edge biomedical technology to empower cancer

We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.

Where does the secreted protein acidic and rich in cysteine (SPARC) protein originate? What leads to its expression? SPARC is secreted from cells. Virtually any cell can produce SPARC. In fact most cells that are adherent in tissue culture produce SPARC at a detectable level. Growth of cells in culture is stressful and SPARC is a protein that is often produced by cells under stress, thus the concept of it as a ‘culture shock’ protein was established. In tissues, cells that are

Epoxidation, Dihydroxylation, and the Utility of Epoxides and Diols Ready Outline: Epoxidation Condensation approaches Darzens condensation Sulfur ylides With organic peroxides Peroxy acids Peroxy iminic acids Dioxiranes DMDO Enantioselective versions Metal-catalyzed Approaches V(O)(acac)2 Sharpless AE Metal Oxo’s MTO Fe, Pt and Mn-based (Salen)Mn Jacobsen AE Epoxide Ring Opening Opening under acid or basic conditions Organocopper additions Reactions of epoxy alcohols Dihydroxylation

Reagent/Reaction Use Ref Note DMSO/DCC (Pfitzner- Moffatt or Moffatt) Alcohol ketone/aldehyde Jacs 1963, 3027; Mech: JACS, 1965, 5561, JOC, 1967, 1926 First DMSO-based; DCC pain to remove; EDCI better DMSO/Ac2O “ Jacs 1967, 2416 DMSO/TFAA “ Jacs, 1975, 2758 DMSO/SO3-Pyridine (Parikh- Doering) “ JACS, 1967, 5505 Often under ambient conditions; best for α-chiral aldehydes/ketones (COCl)2/DMSO (swern) “ JOC, 1978, 2480; mech: Tet. 1978, 1651 Most commonly used; DMSO/Ac2O

Ready; Catalysis Isomerization/cyclization-1 R M R' M R R' H R R' M H MH R R' H R' M M H Olefin insertion into Metal alkyl can be followed by hydride elimination or additional olefin insertions: -dimerization/oligomerization -small molecules -polymerization Recall: electron rich M (late transition metal) Keq < 1 ->dimerization, etc electron poor M (early transition metal) Keq > 1 ->polymerization P Ph2 Ni OO H C7-C14 C1-C3 HO C10-C18 C1-C3 C7-C14 Shell

1 Ready; Catalysis Hydrogenation Categories and Dichotomies: Heterogeneous or Homogeneous Neutral or Cationic Directed or Non-directed Heterolytic or Homolytic H2 Activation Racemic or Enantioselective Syn or Trans Addition Homogeneous Hydrogenation Rh Ph3P Ph3P Cl PPh3 Advantages: Mild conditions Improved selectivity Directed Hydrogenation Enantioselective Hydrogenation Mechanistically accessible Disadvantages: Purification $$$$ Often less

Ready; Catalysis Intro Helpful Texts: Principles and Applications of Organotransition Metal Chemistry, Collman, Hegedus, Norton, Fink The Organometallic Chemistry of the Transition Metals, Crabtree; Prof. M-Christina White’s lecture notes: http://www.courses.fas.harvard.edu/~chem153/ (many of my notes are taken from these, with permission) Advanced Synthesis and Catalysis, Spring 2011 Or: How to make more molecules more complex more quickly with less effort/material/waste