Minireview Shape-specific polymeric nanomedicine: emerging opportunities and challenges Li Tao1, Walter Hu1, Yaling Liu2, Gang Huang3, Baran D Sumer4 and Jinming Gao3 1Erik Johnsson School of Engineering & Computer Science, University of Texas at Dallas, Richardson, TX 75080; 2Department of Mechanical Engineering and Mechanics, Lehigh University, 19 Memorial Drive West, Bethlehem, PA 18015; 3Department of Pharmacology, Harold C Simmons Comprehensive Cancer Center; 4Department of

Author's personal copy Off-resonance saturation MRI of superparamagnetic nanoprobes: Theoretical models and experimental validations Chalermchai Khemtong a, Osamu Togao b, Jimin Ren b, Chase W. Kessinger a, Masaya Takahashi b, A. Dean Sherry b, Jinming Gao a,⇑ a Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, United States b The Advanced Imaging Research Center, University

Journal of Controlled Release 151 (2011) 271–277 Contents lists available at ScienceDirect Journal of Controlled Release j ourna l homepage: www.e lsev ie r.com/ locate / jconre l N A N O M E D IC IN E Nanoscopic micelle delivery improves the photophysical properties and efficacy of photodynamic therapy of protoporphyrin IX Huiying Ding a, Baran D. Sumer c, Chase W. Kessinger a, Ying Dong a,b, Gang Huang a, David A. Boothman a,b, Jinming Gao a,⁎ a Department of Pharmacology, University of

Functional Nanoparticles DOI: 10.1002/anie.201100884 Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells** Kejin Zhou, Yiguang Wang, Xiaonan Huang, Katherine Luby-Phelps, Baran D. Sumer, and Jinming Gao* In recent years, multifunctional nanoparticles have received considerable attention in many applications such as biosen- sors, diagnostic nanoprobes, and targeted drug delivery.[1] These efforts have been driven to a large extent by the

J O U R N A L O F M A T E R I A L S S C I E N C E 3 9 (2 0 0 4 ) 1429 – 1432 Size-controlled polyelectrolyte nanocapsules via layer-by-layer self-assembly H. AI , J . GAO Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 E-mail: jinming@cwru.edu Nanomaterials have found many important applica- tions in biomedical, pharmaceutical, electronic, and molecular diagnostic fields. The recent introduction of electrostatic layer-by-layer (LbL) self-assembly

Original Investigations Quantitative Computed Tomography Analysis of Local Chemotherapy in Liver Tissue After Radiofrequency Ablation1 Agata A. Exner, PhD, Brent D. Weinberg, BS, Nicholas T. Stowe, PhD, Anthony Gallacher, MS, David L. Wilson, PhD, John R. Haaga, MD, Jinming Gao, PhD Rationale and Objectives. Computed tomography (CT) was used to noninvasively monitor local drug pharmacokinetics from polymer implants in rat livers before and following radiofrequency ablation. Materials and

Development of B-Lapachone Prodrugs forTherapyAgainst Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase1Levels Kathryn E. Reinicke,1,2 Erik A. Bey,1,3 Melissa S. Bentle,1,4 JohnJ. Pink,1,3 Stephen T. Ingalls,4,6 Charles L. Hoppel,4,6,7 Rosana I. Misico,8 GiselaM. Arzac,8 Gerardo Burton,8William G. Bornmann,9 Damon Sutton,5 Jinming Gao,5 and David A. Boothman1,3,4 Abstract B-Lapachone, an o-naphthoquinone, induces a novel caspase- and p53-independent apoptotic

B � p o A r c B O S 6 P Int. J. Radiation Oncology Biol. Phys., Vol. 61, No. 1, pp. 212–219, 2005 Copyright © 2005 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/05/$–see front matter doi:10.1016/j.ijrobp.2004.09.018 IOLOGY CONTRIBUTION SUSCEPTIBILITY OF CANCER CELLS TO �-LAPACHONE IS ENHANCED BY IONIZING RADIATION HEON JOO PARK, M.D., PH.D.,*† KI-JUNG AHN, M.D.,* SEUNG-DO AHN, M.D.,‡ EUNKYUNG CHOI, M.D., PH.D.,‡ SANG WOOK LEE, M.D.,‡ BRENT WILLIAMS, B.S.,* EUN JUNG KIM

©200 5 L ANDES BIOSCI EN CE. DO NOT D IST RIBUTE. [Cancer Biology & Therapy 4:1, 95-102, January 2005]; ©2005 Landes Bioscience Matthew Ough4 Anne Lewis4 Erik A. Bey6 Jinming Gao6 Justine M. Ritchie3 William Bornmann7 David A. Boothman6 Larry W. Oberley2,3,4 Joseph J. Cullen1,2,3,4,5,* Departments of 1Surgery, 2Radiation Oncology and the 3Holden Comprehensive Cancer Center; 4University of Iowa College of Medicine; Iowa City, Iowa USA 5Veterans Affairs Medical Center; Iowa City

null