Search

Folate-functionalized polymeric micelles for tumor targeted delivery of a potent multidrug-resistance modulator FG020326 Xiaoqiang Yang,1* Wenjing Deng,2* Liwu Fu,2 Elvin Blanco,3 Jinming Gao,3 Daping Quan,1 Xintao Shuai1 1BME Center, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China 2Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China 3Simmons Comprehensive Cancer Center

1 Ready; Catalysis Organometallics: Definitions Organometallics: Hard to define usefully and completely at the same time, but generally: Compounds containing metal-carbon bond(s). Fe Cl Ti Cl Cl ClFe NC NC CN CN CN CN K3 No question: Organometallic No question: Inorganic ???? Catalysis further complicates the issue: CH3 Br CH3 (HO)2B H3C + Me2N PCy2 PdL L H3C CH3 CH3 CH3 CH3 CH3 2% Pd(OAc)2 3% L CsF, rt L = Buchwald, JACS, 1998, 9722

Imprinted large-scale high density polymer nanopillars for organic solar cells Mukti Aryal and Fatih Buyukserin Department of Electrical Engineering, University of Texas at Dallas, Richardson, Texas 75080 Kamil Mielczarek Department of Physics, University of Texas at Dallas, Richardson, Texas 75080 Xiao-Mei Zhao Department of Electrical Engineering, University of Texas at Dallas, Richardson, Texas 75080 Jinming Gao Department of Chemistry, University of Texas at Dallas, Richardson, Texas

1 P(tBu)2 P(tBu)2 CuBr P Pd P P P PBu3 Pt H Et3P Cl PEt3 Ir S R3P H PR3 H S -S PF6 - Ir S R3P H PR3 H P P Pd PF6 - Pt H Et3P Cl PEt3 Py P P Ir S R3P H PR3 H PF6 - Pt H Et3P Py PEt3 Cl Fe Pt H Et3P Py PEt3 P P Cl- Organometallic Reaction Mechanisms Ligand association/dissociation + toluene insoluble (PBu3)nCuBr soluble + active catalyst for cross coupling = NOTE: No ox. state change Ligand Exchange: Associative - common for 16e- complexes

lable at ScienceDirect Biomaterials 30 (2009) 1962–1970 Contents lists avai Biomaterials journal homepage: www.elsevier .com/locate/biomater ia ls MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression Chen Guihuaa,*,1, Chen Wenjiea,1, Wu Zhuanga,1, Yuan Renxub,1, Li Huaa, Gao Jinmingc, Shuai Xintaob,** a Liver Transplantation Center, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China b Center of

Substrate pKa's. Numbers are approximations for outside the range -2 - 16, but useful to know. For an extensive list, see http://www.chem.wisc.edu/areas/reich/pkatable/ Inorganics H2O DMSO CF3SO3H -14 HCl -8 H3O+ -2 H2O 16 NH4Cl 9 Organic X-H AcOH 5 12 O+ CH3Ph H -6 Me2OH+ -4 CH3SO3H -3 2 NH+ 5 3 N H O H 15 26 MeOH 16 28 17 29 NH3 36 38 41 EWG-CH NO2-CH3 10 17 O O 9 13 O EtO O 11 14 O EtO OEt O 13 16 O 20 27 O t-BuO 25 30 O Me2N 35 O S 3533PhOH 10 18

MINIREVIEW Multifunctional Micellar Nanomedicine for Cancer Therapy ELVIN BLANCO,* CHASE W. KESSINGER,* BARAN D. SUMER,� AND JINMING GAO*,1 *Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390; and �Department of Otolaryngology, Southwestern Medical School, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235 Polymeric micelles are supramolecular, core-shell nanoparticles

Ready; Catalysis Nonlinear Effects Outline Definitions Origins of nonlinear effects in enantioselective reactions ML2 model Reservoir model Transition-state model Kinetic aspects of nonlinear effects Asymmetric amplification Cool tricks Origin of biotic asymmetry? Key reviews Kagan, ACIEE, 1998, 2922 (a pretty complete review, source of many of my figures) Kagan, Advanced Syn. Cat., 2001, 227 (an overview) Blackmond, Accts, 2000, 402 (kinetic aspects) Soai

Intratumoral Delivery of B-Lapachone via Polymer Implants for Prostate Cancer Therapy Ying Dong,1Shook-Fong Chin,1Elvin Blanco,1Erik A. Bey,1Wareef Kabbani,2 Xian-Jin Xie,1,3 William G. Bornmann,4 David A. Boothman,1andJinming Gao1 Abstract Purpose: h-Lapachone (ARQ 501, a formulation of h-lapachone complexed with hydroxy- propyl-h-cyclodextrin) is a novel anticancer agent with selectivity against prostate cancer cells overexpressing theNAD(P)H:quinone oxidoreductase-1enzyme. Lackof solubility

Ready; Catalysis Intro Helpful Texts: Principles and Applications of Organotransition Metal Chemistry, Collman, Hegedus, Norton, Fink The Organometallic Chemistry of the Transition Metals, Crabtree; Prof. M-Christina White’s lecture notes: http://www.courses.fas.harvard.edu/~chem153/ (many of my notes are taken from these, with permission) Advanced Synthesis and Catalysis, Spring 2011 Or: How to make more molecules more complex more quickly with less effort/material/waste