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Minimal Residual Disease and Metastasis Postdoctoral positions are available in the laboratory of Dr. Srinivas Malladi, Ph.D. - Faculty Profile - UT Southwestern, Department of Pathology at UT Southwestern Medical Center to study the biology of minimal residual disease and metastasis in breast, lung and renal Adenocarcinomas. Malladi Lab - UT Southwestern, Dallas, Texas is focused on understanding how disseminated cancer cells survive, evade immune surveillance and give rise to overt

Meet the Genomics team

We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.

Wakeland Lab's Administration

Skip to main content Publications Featured Publications Bacterial Peptidoglycan Fragments Differentially Regulate Innate Immune Signaling. Bersch KL, DeMeester KE, Zagani R, Chen S, Wodzanowski KA, Liu S, Mashayekh S, Reinecker HC , Grimes CL, ACS Cent Sci 2021 Apr 7 4 688-696 GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses. Kashyap AS, Fernandez-Rodriguez L, Zhao Y, Monaco G, Trefny MP, Yoshida N, Martin K, Sharma A

Skip to main content Publications Featured Publications CCT and CCT-like Modular Protein Interaction Domains in WNK Signaling. Taylor CA, Cobb MH, 2021 Jul Mol Pharmacol WNK1 Enhances Migration and Invasion in Breast Cancer Models. Jaykumar AB, Jung JU, Parida PK, Dang TT, Wichaidit C, Kannangara AR, Earnest S, Goldsmith EJ, Pearson GW, Malladi S, Cobb MH, 2021 Jul Mol Cancer Ther The pancreatic ? cell response to secretory demands and adaption to stress M.A. Kalwat, D. Scheuner, K. Rodrigues

Skip to main content Research A Microtubule-Based Microbial Pattern Recognition System Our work has revealed polymorphisms that show that microbial defense systems could be linked to human autoimmune diseases. Find out more Development of Mucosal Immunity We study human genetic diversity associated with inflammatory bowel diseases to understand the principal mechanisms of mucosal immunity that control the intestinal barrier function and the microbiome. Find out more GEF-H1 Regulation of Anti

Read more Wakeland Lab's research

Skip to main content GEF-H1-Dependent Regulation of Anti-Tumor Immunity We discovered that intracellular activation of the GEF-H1 signaling pathway induces immune responses and dendritic cell maturation similar to microbial pattern recognition receptors. GEF-H1 directed immunity emerges as a critical mechanism that controls dendritic cell maturation upon disruption of microtubules. This immune activation pathway is induced by microtubule destabilization and controls maturation of dendritic cells

Skip to main content Photo Gallery Clint Magda Sachith lab cleaning (Jiung and Magda) Melanie and Wei Chen Cobb lab art collection # 1 Clint and future mini me(?) Clint's big hands are ready for big expt Zaganjor Lab at Vanderbilt Mike won 2nd place poster at Gordon Conference 2019 Dr. Christerson was named a NH State finalist in the PAEMST Jessie English (Tilos Therapeutics) and Mengeng Chen (Merck) Clint, Magda, and Sachith at ASBMB conference in San Diego (2018) Barbara: celebrating 50 years