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ll Review Macroencapsulated bacteria for in vivo sensing and therapeutics Yidan Lyu,1,10 Hao Huang,2,10 Yuyan Su,1,10 Binbin Ying,3,4 Wen-Che Liu,1 Kairu Dong,5 Ningjie Du,2 Robert S. Langer,6,7,* Zhen Gu,1,8,9,* and Kewang Nan1,8,9,* PROGRESS AND POTENTIAL Engineered bacterial therapeutics, with promising preclinical outcomes, are advancing in commercialization endeavors. However, their translation into widely accepted clinical products still poses significant challenges, demanding

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APPL I ED SC I ENCES AND ENG INEER ING Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes Xian Wang1,2, Zheyuan Gong3, Tiancong Wang3, Junhui Law3, Xin Chen1,2,4, Siyi Wanggou1,2,5,6, Jintian Wang3, Binbin Ying3, Michelle Francisco1,2, Weifan Dong1,2,7, Yi Xiong1,2,5,6, Jerry J. Fan1,2,7, Graham MacLeod8, Stephane Angers8,9,10, Xuejun Li5,6, Peter B. Dirks1,2,7, Xinyu Liu3, Xi Huang1,2,7*, Yu Sun3,11,12,13* Glioblastoma (GBM) is the most common

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Article Luminal electrophysiologi cal neuroprofiling system for gastrointestinal neuromuscular diseases Graphical abstract Highlights d The LENS is a luminal electrophysiological neuroprofiling system d The LENS electrophysiologically characterizes the GI tract for disease diagnosis d Analytical metrics are generated to differentiate neuromuscular diseases d High-resolution spatial profiles identify ganglionic- aganglionic transition zones Authors Shriya S. Srinivasan, Sabrina Liu, Ryo

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CELL SCIENCE AT A GLANCE The fusogenic synapse at a glance Ji Hoon Kim1 and Elizabeth H. Chen2,3,* ABSTRACT Cell–cell fusion is a fundamental process underlying fertilization, development, regeneration and physiology of metazoans. It is a multi-step process involving cell recognition and adhesion, actin cytoskeletal rearrangements, fusogen engagement, lipid mixing and fusion pore formation, ultimately resulting in the integration of two fusion partners. Here, we focus on the asymmetric actin

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Articles https://doi.org/10.1038/s41556-018-0106-3 1Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 2Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. 3Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX, USA. 4Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA. 5Departments of Biology and of Biochemistry and Molecular Biology

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