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Journal of Controlled Release 83 (2002) 427–435 www.elsevier.com/ locate/ jconrel C ombined modeling and experimental approach for the development of dual-release polymer millirods *Feng Qian, Gerald M. Saidel, Damon M. Sutton, Agata Exner, Jinming Gao Cancer-Targeted Drug Delivery Laboratory, Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106,USA Received 3 July 2002; accepted 7 August 2002 Abstract This paper describes a

Jiaen Liu, Ph.D. Assistant Professor, Advanced Imaging Research Center and Radiology University of Texas Southwestern Medical Center, Dallas, TX, USA Email: jiaen.liu@utsouthwestern.edu EDUCATION Ph.D. Biomedical Engineering, University of Minnesota, Minneapolis, MN 2015 Minor in Neuroscience, 2011 M.S. Instruments Science and Technology, Tsinghua University, Beijing, China 2007 B.S. Environmental Engineering, Tsinghua University, Beijing, China 2005 RESEARCH EXPERIENCE Assistant Professor

www.elsevier.com/locate/jconrel Journal of Controlled Release 98 (2004) 415–426 Micellar carriers based on block copolymers of poly(q-caprolactone) and poly(ethylene glycol) for doxorubicin delivery Xintao Shuaia,1, Hua Aia,1, Norased Nasongklab, Saejeong Kima, Jinming Gaoa,* aDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA bDepartment of Macromolecular Science and Engineering, Case Western Reserve University, 10900 Euclid

User manual for TYGRESS Tomography-Guided 3D Reconstruction of Subcellular Structures (TYGRESS) is a hybrid method, which combines the advantageous features of both single particle cryo-EM and cryo-ET/subtomogram averaging to provide high-resolution structures of macromolecular complexes within their native, cellular environment. In this method, one typical single particle cryo-EM micrograph is acquired (i.e., with an electron dose that is higher than for individual tilt series

B � p o A r c B O S 6 P Int. J. Radiation Oncology Biol. Phys., Vol. 61, No. 1, pp. 212–219, 2005 Copyright © 2005 Elsevier Inc. Printed in the USA. All rights reserved 0360-3016/05/$–see front matter doi:10.1016/j.ijrobp.2004.09.018 IOLOGY CONTRIBUTION SUSCEPTIBILITY OF CANCER CELLS TO �-LAPACHONE IS ENHANCED BY IONIZING RADIATION HEON JOO PARK, M.D., PH.D.,*† KI-JUNG AHN, M.D.,* SEUNG-DO AHN, M.D.,‡ EUNKYUNG CHOI, M.D., PH.D.,‡ SANG WOOK LEE, M.D.,‡ BRENT WILLIAMS, B.S.,* EUN JUNG KIM

CANCER RESEARCH | MOLECULAR CELL BIOLOGY HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis Yanling Niu1, Lei Bao1, Yan Chen1, ChenliangWang1, Maowu Luo1, Bo Zhang1, Mi Zhou1, Jennifer E. Wang1, Yisheng V. Fang1, Ashwani Kumar2, Chao Xing2,3,4, Yingfei Wang1,5, and Weibo Luo1,6 ABSTRACT ◥ Hypoxia induces a vast array of long noncoding RNAs (lncRNA) in breast cancer cells, but their biological functions remain largely unknown. Here

Development of B-Lapachone Prodrugs forTherapyAgainst Human Cancer Cells with Elevated NAD(P)H:Quinone Oxidoreductase1Levels Kathryn E. Reinicke,1,2 Erik A. Bey,1,3 Melissa S. Bentle,1,4 JohnJ. Pink,1,3 Stephen T. Ingalls,4,6 Charles L. Hoppel,4,6,7 Rosana I. Misico,8 GiselaM. Arzac,8 Gerardo Burton,8William G. Bornmann,9 Damon Sutton,5 Jinming Gao,5 and David A. Boothman1,3,4 Abstract B-Lapachone, an o-naphthoquinone, induces a novel caspase- and p53-independent apoptotic

JCB: Article The Rockefeller University Press   $30.00 J. Cell Biol. Vol. 191 No. 5  1013–1027 www.jcb.org/cgi/doi/10.1083/jcb.201006006 JCB 1013 K.L. Sens and S. Zhang contributed equally to this paper. P. Jin and R. Duan contributed equally to this paper. Correspondence to Elizabeth H. Chen: echen@jhmi.edu Abbreviations used in this paper: Ants, Antisocial; Duf, Dumbfounded; FCM, fusion-competent myoblast; HPF/FS, high pressure freezing/freeze substitution; MMD, multiple membrane

Interactions between self-assembled polyelectrolyte shells and tumor cells Hua Ai,1 John J. Pink,2 Xintao Shuai,1 David A. Boothman,2 Jinming Gao1 1Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106 2Department of Radiation Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106 Received 23 August 2004; revised 22 November 2004; accepted 23 November 2004 Published online 1 April 2005 in

1 Ready; Catalysis Hydrogenation Categories and Dichotomies: Heterogeneous or Homogeneous Neutral or Cationic Directed or Non-directed Heterolytic or Homolytic H2 Activation Racemic or Enantioselective Syn or Trans Addition Homogeneous Hydrogenation Rh Ph3P Ph3P Cl PPh3 Advantages: Mild conditions Improved selectivity Directed Hydrogenation Enantioselective Hydrogenation Mechanistically accessible Disadvantages: Purification $$$$ Often less