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Reagent/Reaction Use Ref Note DMSO/DCC (Pfitzner- Moffatt or Moffatt) Alcohol ketone/aldehyde Jacs 1963, 3027; Mech: JACS, 1965, 5561, JOC, 1967, 1926 First DMSO-based; DCC pain to remove; EDCI better DMSO/Ac2O “ Jacs 1967, 2416 DMSO/TFAA “ Jacs, 1975, 2758 DMSO/SO3-Pyridine (Parikh- Doering) “ JACS, 1967, 5505 Often under ambient conditions; best for α-chiral aldehydes/ketones (COCl)2/DMSO (swern) “ JOC, 1978, 2480; mech: Tet. 1978, 1651 Most commonly used; DMSO/Ac2O

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim www.advhealthmat.de www.MaterialsViews.com wileyonlinelibrary.com 1 C O M M U N IC A TIO N Prodrug Strategy to Achieve Lyophilizable, High Drug Loading Micelle Formulations Through Diester Derivatives of β-Lapachone Xinpeng Ma , Xiumei Huang , Gang Huang , Longshan Li , Yiguang Wang , Xiuquan Luo , David A. Boothman , and

Reactivity Umpolung-1 Ready Reactivity Umpolung: reversal of normal polarity electrophiles become nucleophiles nucleophiles become electrophiles Outline: 1. electrophilic heteroatoms 2. acyl anions 3. homoenolates 4. the cyclopropane trick 5. sulfone chemistry Normal reactivity: X x = heteroatom d = donor (Nu-) a = acceptor (E+) d a d a d X X X X or 1 3 1 5 How to make: X X or X X 1 2 1 4 complimentary

β‑Lapachone and Paclitaxel Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy Ling Zhang,† Zhen Chen,† Kuan Yang,† Chun Liu,† Jinming Gao,‡ and Feng Qian*,† †Department of Pharmacology and Pharmaceutical Sciences and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing 100084, P.R. China ‡Simmons Comprehensive Cancer Center

Zinc ferrite nanoparticles as MRI contrast agentsw Carlos Bárcena, a Amandeep K. Sra, a Girija S. Chaubey, b Chalermchai Khemtong, a J. Ping Liu b and Jinming Gao* a Received (in Cambridge, UK) 21st January 2008, Accepted 15th February 2008 First published as an Advance Article on the web 11th March 2008 DOI: 10.1039/b801041b Mixed spinel hydrophobic ZnxFe1�xO�Fe2O3 (up to x = 0.34) nanoparticles encapsulated in polymeric micelles exhibited in- creased T2 relaxivity and sensitivity

lable at ScienceDirect Polymer 49 (2008) 3477–3485 Contents lists avai Polymer journal homepage: www.elsevier .com/locate/polymer Folate-encoded and Fe3O4-loaded polymeric micelles for dual targeting of cancer cells Xiaoqiang Yang a,1, Yinghua Chen b,1, Renxu Yuan a, Guihua Chen b, Elvin Blanco c, Jinming Gao c, Xintao Shuai a,* a BME Center, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou

Original Investigations Quantitative Computed Tomography Analysis of Local Chemotherapy in Liver Tissue After Radiofrequency Ablation1 Agata A. Exner, PhD, Brent D. Weinberg, BS, Nicholas T. Stowe, PhD, Anthony Gallacher, MS, David L. Wilson, PhD, John R. Haaga, MD, Jinming Gao, PhD Rationale and Objectives. Computed tomography (CT) was used to noninvasively monitor local drug pharmacokinetics from polymer implants in rat livers before and following radiofrequency ablation. Materials and

  In vivo Off-Resonance Saturation Magnetic Resonance Imaging of AvB3-Targeted Superparamagnetic Nanoparticles Chalermchai Khemtong, 1 Chase W. Kessinger, 1 Jimin Ren, 2 Erik A. Bey, 1 Su-Geun Yang, 1 Jagadeesh Setti Guthi, 1 David A. Boothman, 1 A. Dean Sherry, 2 and Jinming Gao 1 1Department of Pharmacology, Simmons Comprehensive Cancer Center and 2The Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas Abstract Magnetic resonance

Combined radiofrequency ablation and doxorubicin- eluting polymer implants for liver cancer treatment Brent D. Weinberg,1 Elvin Blanco,2 Scott F. Lempka,1 James M. Anderson,3 Agata A. Exner,4 Jinming Gao2 1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 2Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 3Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106 4Department

communications 1632 Nanoimprint lithography Fabrication of Polymeric Nanorods Using Bilayer Nanoimprint Lithography** Fatih Buyukserin, Mukti Aryal, Jinming Gao, and Wenchuang Hu* Polymeric nanoparticles are becoming increasingly important in a variety of biological applications, such as biomolecular sensing, diagnostic imaging, and therapeutic drug delivery.[1,2] For these applications, the mass production of multifunctional nanocomposite materials with precise control of particle size