Harold C. Simmons Comprehensive Cancer Center Bioinformatics Data Science Shared Resource Data Science On-Demand User Agreement SCCC-DSSR This agreement is between the DSSR client named below and the Director of SCCC-DSSR, Professor Jeon Lee. By signing this document, user acknowledges and agrees to the conditions listed below. DSSR client (Full Name

YU ET AL . VOL. 5 ’ NO. 11 ’ 9246–9255 ’ 2011 www.acsnano.org 9246 October 19, 2011 C 2011 American Chemical Society Overcoming Endosomal Barrier by Amphotericin B-Loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery Haijun Yu,† Yonglong Zou,†,‡ Yiguang Wang,† Xiaonan Huang,† Gang Huang,† Baran D. Sumer,§ David A. Boothman,†,‡ and Jinming Gao†,* †Department of Pharmacology, ‡Department of Radiation Oncology, and §Department of Otolaryngology, Simmons Comprehensive Cancer

Oxidations at Carbon General references March, Advanced Org Chem, 1992, 1158-1238 Trost, Comp. Org. Syn. 1991, vol 7 Carey and Sundberg, Advanced Org Chem, part B, 615-664 Smith, Org Syn, Chap 3 H CH3 C(-IV) R CH3 C(-III) R CH2 OH C(-1) R CH OH RR H2 C R C(-II) R C O R C(0) R CH O C(+I) H CH2 OH C(-II) H CH O C(0) C(II) R COR O C(+III) H COH O C(+II) O C O C(+IV) RO COR O C(+IV) alkane RCH2M RCH2SiR3 RCH2X X=halide RCH2NR2 RCH2SR RCH2PR2 Acetal: RCH(OR)2

    2012;72:3038-3047. Published OnlineFirst April 24, 2012.Cancer Res   Xiumei Huang, Ying Dong, Erik A. Bey, et al.   Kills by PARP1-Induced Programmed Necrosis An NQO1 Substrate with Potent Antitumor Activity That Selectively         Updated Version 10.1158/0008-5472.CAN-11-3135doi: Access the most recent version of this article at: Material Supplementary http://cancerres.aacrjournals.org/content/suppl/2012/04/24/0008-5472.CAN-11-3135.DC1.html Access the most recent supplemental

Reactivity Umpolung-1 Ready Reactivity Umpolung: reversal of normal polarity electrophiles become nucleophiles nucleophiles become electrophiles Outline: 1. electrophilic heteroatoms 2. acyl anions 3. homoenolates 4. the cyclopropane trick 5. sulfone chemistry Normal reactivity: X x = heteroatom d = donor (Nu-) a = acceptor (E+) d a d a d X X X X or 1 3 1 5 How to make: X X or X X 1 2 1 4 complimentary

Functional Nanoparticles DOI: 10.1002/anie.201100884 Tunable, Ultrasensitive pH-Responsive Nanoparticles Targeting Specific Endocytic Organelles in Living Cells** Kejin Zhou, Yiguang Wang, Xiaonan Huang, Katherine Luby-Phelps, Baran D. Sumer, and Jinming Gao* In recent years, multifunctional nanoparticles have received considerable attention in many applications such as biosen- sors, diagnostic nanoprobes, and targeted drug delivery.[1] These efforts have been driven to a large extent by the

Epoxidation, Dihydroxylation, and the Utility of Epoxides and Diols Ready Outline: Epoxidation Condensation approaches Darzens condensation Sulfur ylides With organic peroxides Peroxy acids Peroxy iminic acids Dioxiranes DMDO Enantioselective versions Metal-catalyzed Approaches V(O)(acac)2 Sharpless AE Metal Oxo’s MTO Fe, Pt and Mn-based (Salen)Mn Jacobsen AE Epoxide Ring Opening Opening under acid or basic conditions Organocopper additions Reactions of epoxy alcohols Dihydroxylation

Dynamic Article LinksC<Lab on a Chip Cite this: Lab Chip, 2011, 11, 1952 www.rsc.org/loc PAPER D ow nl oa de d by U ni ve rs ity o f T ex as a t D al la s on 0 3 Ju ly 2 01 1 Pu bl is he d on 1 9 A pr il 20 11 o n ht tp :// pu bs .r sc .o rg | do i:1 0. 10 39 /C 0L C 00 60 5J View Online Ultrasensitive protein detection using lithographically defined Si multi- nanowire field effect transistors† Ruhai Tian,ab Suresh Regonda,a Jinming Gao,b

Protecting Groups in Organic Synthesis-1 Ready Protecting groups are a sad fact of synthetic chemistry They are usually needed, but rarely desired Many syntheses have stalled because of trouble putting on or removing protecting groups 4 basic questions to address when choosing a P.G.: 1. Can I put it on where and only where I want? 2. Can I take it and only it off? 3. Will it survive all future reaction conditions? 4. Will it

Multicolored pH-Tunable and Activatable Fluorescence Nanoplatform Responsive to Physiologic pH Stimuli Kejin Zhou,† Haoming Liu,‡ Shanrong Zhang,†,§ Xiaonan Huang,† Yiguang Wang,† Gang Huang,† Baran D. Sumer,∥ and Jinming Gao*,†,⊥ †Department of Pharmacology, Simmons Comprehensive Cancer Center, ‡Department of Biochemistry, §Advanced Imaging Research Center, and ∥Department of Otolaryngology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States ⊥Department of