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Article Luminal electrophysiologi cal neuroprofiling system for gastrointestinal neuromuscular diseases Graphical abstract Highlights d The LENS is a luminal electrophysiological neuroprofiling system d The LENS electrophysiologically characterizes the GI tract for disease diagnosis d Analytical metrics are generated to differentiate neuromuscular diseases d High-resolution spatial profiles identify ganglionic- aganglionic transition zones Authors Shriya S. Srinivasan, Sabrina Liu, Ryo

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JCB: Article The Rockefeller University Press   $30.00 J. Cell Biol. Vol. 199 No. 1  169–185 www.jcb.org/cgi/doi/10.1083/jcb.201204065 JCB 169 R. Duan and P. Jin contributed equally to this paper. Correspondence to Elizabeth H. Chen: echen@jhmi.edu Abbreviations used in this paper: AID, auto-inhibitory domain; DPak, Drosophila p21-activated kinase; Duf, Dumbfounded; Eve, Even skipped; FCM, fusion- competent myoblast; MHC, myosin heavy chain; NPF, nucleation-promoting factor; PAK, p21

ARTICLE Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery F. J. Voskuil 1,13, P. J. Steinkamp 2,13, T. Zhao3, B. van der Vegt 4, M. Koller2, J. J. Doff4, Y. Jayalakshmi3, J. P. Hartung5, J. Gao 6,7, B. D. Sumer 6✉, M. J. H. Witjes1, G. M. van Dam 2,8✉ & the SHINE study group* Cancer cell metabolism leads to a uniquely acidic microenvironment in solid tumors, but exploiting the labile extracellular pH differences

Requirement of the fusogenic micropeptide myomixer for muscle formation in zebrafish Jun Shia,b,1, Pengpeng Bia,b,c,1, Jimin Peid, Hui Lia,b,c, Nick V. Grishind,e, Rhonda Bassel-Dubya,b,c, Elizabeth H. Chena,b,2, and Eric N. Olsona,b,c,2 aDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390; bHamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390; cSenator Paul D. Wellstone Muscular

NATURE BIOMEDICAL ENGINEERING 1, 0006 (2016) | DOI: 10.1038/s41551-016-0006 | www.nature.com/natbiomedeng 1 ARTICLES PUBLISHED: 19 DECEMBER 2016 | VOLUME: 1 | ARTICLE NUMBER: 0006 A transistor-like pH nanoprobe for tumour detection and image-guided surgery Tian Zhao1​†, Gang Huang1, Yang Li1, Shunchun Yang1, Saleh Ramezani2, Zhiqiang Lin1, Yiguang Wang1, Xinpeng Ma1, Zhiqun Zeng1, Min Luo1, Esther de Boer3, Xian-Jin Xie4, Joel Thibodeaux5, Rolf A. Brekken6, Xiankai Sun2, Baran D. Sumer7

Mechanisms of myoblast fusion during muscle development Ji Hoon Kim1, Peng Jin1, Rui Duan1, and Elizabeth H. Chen1,2 1Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 Abstract The development and regeneration of skeletal muscles require the fusion of mononulceated muscle cells to form multinucleated, contractile muscle fibers. Studies using a simple genetic model, Drosophila melanogaster, have discovered many evolutionarily

Theranostics 2020, Vol. 10, Issue 7 http://www.thno.org 3340 Theranostics 2020; 10(7): 3340-3350. doi: 10.7150/thno.41239 Research Paper Detection of Lymph Node Metastases by Ultra-pH-Sensitive Polymeric Nanoparticles Zachary T. Bennett1, Qiang Feng1, Justin A. Bishop2, Gang Huang1, Baran D. Sumer3, and Jinming Gao1,3 1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. 2

People & Ideas JCB • VOLUME 206 • NUMBER 5 • 2014576 M ost cells in the body are solo entities, self-contained within a cell membrane. But there are certain cases in which cells meld together. Skeletal muscle cells, for example, are multinucleate syncytia that form through the process of cell–cell fusion. Osteo- clasts, a type of cell involved in bone remodeling, also fuse together to promote better bone resorption. And you would not be reading this article were it not for a

Articles https://doi.org/10.1038/s41551-019-0416-1 1Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA. 2Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA. 3Children’s Research Institute, Departments of Pediatrics, Neuroscience, and Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA. 4Department of Otolaryngology, University of Texas Southwestern