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6418 Chem. Commun., 2013, 49, 6418--6420 This journal is c The Royal Society of Chemistry 2013 Cite this: Chem. Commun.,2013, 49, 6418 A novel class of polymeric pH-responsive MRI CEST agents† Shanrong Zhang,ab Kejin Zhou,a Gang Huang,a Masaya Takahashi,b A. Dean Sherry*bc and Jinming Gao*ac In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange

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Characterization of Lung Cancer by Amide Proton Transfer (APT) Imaging: An In-Vivo Study in an Orthotopic Mouse Model Osamu Togao1, Chase W. Kessinger2, Gang Huang2, Todd C. Soesbe1, Koji Sagiyama1, Ivan Dimitrov1, A. Dean Sherry1, Jinming Gao2, Masaya Takahashi1* 1Advanced Imaging Research Center, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, Texas, United States of America, 2Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center

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Polymer Chemistry PAPER Cite this: DOI: 10.1039/c6py01104g Received 24th June 2016, Accepted 30th August 2016 DOI: 10.1039/c6py01104g www.rsc.org/polymers Non-covalent interactions in controlling pH-responsive behaviors of self-assembled nanosystems† Yang Li,a Zhaohui Wang,a Qi Wei,a,b Min Luo,a Gang Huang,a Baran D. Sumerc and Jinming Gao*a Self-assembly and associated dynamic and reversible non-covalent interactions are the basis of protein biochemistry (e.g., protein folding) and the

Advanced Drug Delivery Reviews xxx (2016) xxx–xxx ADR-13057; No of Pages 10 Contents lists available at ScienceDirect Advanced Drug Delivery Reviews j ourna l homepage: www.e lsev ie r .com/ locate /addr Investigation of endosome and lysosome biology by ultra pH-sensitive nanoprobes☆ Chensu Wang a,b, Tian Zhao a, Yang Li a, Gang Huang a, Michael A. White b, Jinming Gao a,⁎ a Department of Pharmacology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323

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A Novel Lanreotide-Encoded Micelle System Targets Paclitaxel to the Tumors with Overexpression of Somatostatin Receptors Nan Zheng,† Wenbing Dai,† Wenwen Du,† Haoran Zhang,† Liandi Lei,† Hua Zhang,† Xueqing Wang,† Jiancheng Wang,† Xuan Zhang,† Jinming Gao,‡ and Qiang Zhang*,† †State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, People’s Republic of China ‡Harold C. Simmons Comprehensive Cancer Center, Department of Pharmacology

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Imaging Agents DOI: 10.1002/anie.201301135 Multi-Chromatic pH-Activatable 19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes** Xiaonan Huang, Gang Huang, Shanrong Zhang, Koji Sagiyama, Osamu Togao, Xinpeng Ma, Yiguang Wang, Yang Li, Todd C. Soesbe, Baran D. Sumer, Masaya Takahashi, A. Dean Sherry, and Jinming Gao* Magnetic resonance imaging (MRI) is a powerful non- invasive imaging technique that has greatly impacted basic biological research as well clinical