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Developmental Cell, Vol. 1, 705–715, November, 2001, Copyright 2001 by Cell Press Antisocial, an Intracellular Adaptor Protein, Is Required for Myoblast Fusion in Drosophila founder cells while the remaining twist-expressing cells become fusion competent (for reviews, see Baylies et al., 1998; Frasch, 1999). It is believed that the founder Elizabeth H. Chen and Eric N. Olson1 Department of Molecular Biology University of Texas Southwestern Medical Center at Dallas cells serve as sources of

Where does the secreted protein acidic and rich in cysteine (SPARC) protein originate? What leads to its expression? SPARC is secreted from cells. Virtually any cell can produce SPARC. In fact most cells that are adherent in tissue culture produce SPARC at a detectable level. Growth of cells in culture is stressful and SPARC is a protein that is often produced by cells under stress, thus the concept of it as a ‘culture shock’ protein was established. In tissues, cells that are

Unveiling the Mechanisms of Cell-Cell Fusion Elizabeth H. Chen1* and Eric N. Olson2* Cell-cell fusion is fundamental to the development and physiology of multicellular organisms, but little is known of its mechanistic underpinnings. Recent studies have revealed that many proteins involved in cell-cell fusion are also required for seemingly unrelated cellular processes such as phagocytosis, cell migration, axon growth, and synaptogenesis. We review advances in understanding cell-cell fusion by

Advanced Synthesis and Catalysis, 2006 Unless noted, class is 9:00-10:30, mon and wed, L4.14 Date Topic Lecturer 8-22 Intro to catalysis Ready 8-24 Organometallics: structure/reactivity-1 Ready 8-29 Organometallics: structure/reactivity-2 Ready 8-31 Kinetics and mech-1 Ready 9-5 Kinetics and mech-2 Ready 9-7 Kinetic resolutions Ready 9-12 Nonlinear effects Ready 9-14 Addns to pi bonds-1 Ready 9-19 Addns to pi bonds-2 Ready 9-21 Addns to pi bonds-3 Ready 9-26 Conjugate addition-1 Ready 9-28

Invasive Podosomes and Myoblast Fusion Elizabeth H. Chen Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA I. OVERVIEW Myoblast fusion is critical for the development, maintenance, and regeneration of skeletal muscles. Despite the identification of many fusion-related molecules in the past decades, the cellular mechanics of myoblast membrane fusion have just begun to be understood. Recent studies using the fruit fly

Department of Radiation Oncology 2280 Inwood Road, Dallas, Texas 75390-9303 Phone: 214-645-8525 Fax: 214-645-8526 utsouthwestern.edu Postdoctoral Fellow in Biomedical Optics and Medical Physics We are seeking skilled and enthusiastic candidates for Postdoctoral Fellow positions in the Biomedical Imaging and Radiation Technology Laboratory (BIRTLab). Our mission is to innovate, develop, and apply cutting- edge biomedical technology to empower cancer

| PERSPECTIVES Sex and the Single Fly: A Perspective on the Career of Bruce S. Baker Deborah J. Andrew,* Elizabeth H. Chen,†,‡,§ Devanand S. Manoli,**,†† Lisa C. Ryner,‡‡ and Michelle N. Arbeitman§§,1 *Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, †Department of Molecular Biology, ‡Department of Cell Biology, §and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390

1 P(tBu)2 P(tBu)2 CuBr P Pd P P P PBu3 Pt H Et3P Cl PEt3 Ir S R3P H PR3 H S -S PF6 - Ir S R3P H PR3 H P P Pd PF6 - Pt H Et3P Cl PEt3 Py P P Ir S R3P H PR3 H PF6 - Pt H Et3P Py PEt3 Cl Fe Pt H Et3P Py PEt3 P P Cl- Organometallic Reaction Mechanisms Ligand association/dissociation + toluene insoluble (PBu3)nCuBr soluble + active catalyst for cross coupling = NOTE: No ox. state change Ligand Exchange: Associative - common for 16e- complexes

GE53CH02_Chen ARjats.cls June 17, 2019 14:52 Annual Review of Genetics DrosophilaMyoblast Fusion: Invasion and Resistance for the Ultimate Union Donghoon M. Lee1 and Elizabeth H. Chen1,2 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; email: Elizabeth.Chen@UTSouthwestern.edu 2Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA Annu. Rev. Genet. 2019. 53:2.1–2.25 The Annual Review

Protecting Groups in Organic Synthesis-1 Ready Protecting groups are a sad fact of synthetic chemistry They are usually needed, but rarely desired Many syntheses have stalled because of trouble putting on or removing protecting groups 4 basic questions to address when choosing a P.G.: 1. Can I put it on where and only where I want? 2. Can I take it and only it off? 3. Will it survive all future reaction conditions? 4. Will it