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β‑Lapachone and Paclitaxel Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy Ling Zhang,† Zhen Chen,† Kuan Yang,† Chun Liu,† Jinming Gao,‡ and Feng Qian*,† †Department of Pharmacology and Pharmaceutical Sciences and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Tsinghua University, Beijing 100084, P.R. China ‡Simmons Comprehensive Cancer Center

German Edition: DOI: 10.1002/ange.201610302Drug Delivery International Edition: DOI: 10.1002/anie.201610302 A Redox-Activatable Fluorescent Sensor for the High-Throughput Quantification of Cytosolic Delivery of Macromolecules Zhaohui Wang+, Min Luo+, Chengqiong Mao, Qi Wei, Tian Zhao, Yang Li, Gang Huang, and Jinming Gao* Abstract: Efficient delivery of biomacromolecules (e.g., proteins, nucleic acids) into cell cytosol remains a critical challenge for the development of macromolecular

Theranostics 2020, Vol. 10, Issue 7 http://www.thno.org 3340 Theranostics 2020; 10(7): 3340-3350. doi: 10.7150/thno.41239 Research Paper Detection of Lymph Node Metastases by Ultra-pH-Sensitive Polymeric Nanoparticles Zachary T. Bennett1, Qiang Feng1, Justin A. Bishop2, Gang Huang1, Baran D. Sumer3, and Jinming Gao1,3 1. Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. 2

Journal of Controlled Release 329 (2021) 353–360 Available online 7 December 2020 0168-3659/© 2020 Elsevier B.V. All rights reserved. Antigen folding improves loading efficiency and antitumor efficacy of PC7A nanoparticle vaccine Jonathan Wilhelm, Manuel Quiñones-Pérez, Jian Wang, Xu Wang, Vijay S. Basava, Jinming Gao * Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75390

ARTICLE Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery F. J. Voskuil 1,13, P. J. Steinkamp 2,13, T. Zhao3, B. van der Vegt 4, M. Koller2, J. J. Doff4, Y. Jayalakshmi3, J. P. Hartung5, J. Gao 6,7, B. D. Sumer 6✉, M. J. H. Witjes1, G. M. van Dam 2,8✉ & the SHINE study group* Cancer cell metabolism leads to a uniquely acidic microenvironment in solid tumors, but exploiting the labile extracellular pH differences

Seminars in Immunology xxx (xxxx) xxx Please cite this article as: Zachary T. Bennett, Seminars in Immunology, https://doi.org/10.1016/j.smim.2021.101580 1044-5323/© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Polyvalent design in the cGAS-STING pathway Zachary T. Bennett a, Suxin Li a, Baran D. Sumer b, Jinming Gao a,b,c,* a Department of Pharmacology, Harold C. Simmons

Skip to main content Search Labs A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z Lab Name or Principal Investigator Centers/Institutes Advanced Imaging Research Center Cecil H. and Ida Green Center for Reproductive Biology Sciences Center for Alzheimer's and Neurodegenerative Diseases Center for Hypothalamic Research Center for Organogenesis Research and Trauma Center for the Genetics of Host Defense Charles and Jane Pak Center for Mineral

Eugene McDermott Center for Human Growth and Development Southwestern Medical School 5323 Harry Hines Blvd. / Dallas, Texas 75390-8591 (214) 648-1695 Fax (214) 648-1666 Email: chao.xing@utsouthwestern.edu Computational Biologist I The laboratories of Dr. Ralph DeBerardinis at Children’s Research Institute (https://cri.utsw.edu/scientists/ralph-deberardinis-laboratory/) and Dr. Chao Xing at McDermott Center for Human Growth and Development (https://labs.utsouthwestern.edu

Please contact Dr. Ralph Mason at ralph.mason@utsouthwestern.edu for more information. DATE SPEAKER TITLE LOCATION Friday, November 22, 2019 Rathan Subramaniam, MD, PhD, MPH Professor of Radiology Chief, Division of Nuclear Medicine UT Southwestern “Neuroendocrine Tumor and Prostate Cancer Theranosis – UT Southwestern Experience” K2.610 Friday, January 24, 2020 Brian W. Pogue, PhD MacLean Professor Engineering Science Director of MS Meg

1 FRDA fibroblasts Short alleles <499 repeats Medium alleles 500 – 999 repeats Long alleles >1000 repeats B - indicates line established from a second, independent skin biopsy of the same individual Cell Line Sex Sampling Age Age of Onset GAA repeats Allele 1 Allele 2 4 M 30 11 597 848 21 M 35 8 622 738 50 M 33 13 353 616 66 M 70 41 110 590 68 F 21 7 570 1200 86 F 30 18 367 780 88 F 50 16 520 520 90 F 29 7 556 556 90B F 33 7 570 570 130 M 56 41