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Researchers at UT Southwestern Medical Center have discovered that a diet free of the amino acid tryptophan can effectively halt the growth of liver cancer in mice. Their findings, published in Nature Communications, offer new insights for dietary-based cancer treatments and highlight the critical role of the tryptophan metabolite indole 3-pyruvate in liver tumor development.

A UT Southwestern Medical Center study of hundreds of underserved women showed that depression and anxiety, in addition to physical factors such as a higher body mass index and previous births, are associated with lingering postpartum urinary incontinence. The findings, published in Urogynecology, shine a spotlight on these conditions that can carry stigmas but are largely treatable, researchers say.

– Sex-specific differences in the knee joint should be considered as early as childhood to help prevent higher incidence and severity of knee osteoarthritis (OA) in women later in life, UT Southwestern Medical Center researchers propose in a review of clinical data.

UT Southwestern Medical Center is the No. 1 hospital in Dallas-Fort Worth for the eighth consecutive year and ranks among the nation’s top hospitals for care in 11 specialties – the most of any hospital in Texas, according to U.S. News & World Report’s annual Best Hospitals list released today.

Hepatocellular carcinoma (HCC), the most common type of liver cancer, can place a significant financial burden on patients, according to an analysis led by a researcher at UT Southwestern Medical Center.

When cancer cells metastasize, breaking away from the primary tumor and spreading to blood, tissue, or lymph nodes, the disease is at its most lethal.

Researchers at UT Southwestern Medical Center developed nanoparticles that successfully edited the disease-causing gene in the lungs of a mouse model of cystic fibrosis (CF), swapping a mutated form for a healthy one that persisted in stem cells. Their findings, reported in Science, could offer hope for people with CF and other debilitating genetic lung diseases.

Two studies led by the Chahrour Lab at UT Southwestern Medical Center shed new light on genes associated with autism spectrum disorder (ASD), the neurodevelopmental disease characterized by impaired communication, abnormal social interactions, and restricted, repetitive behaviors.

Much like human beings, songbirds learn how to vocalize from their parents. Males imitate songs from their fathers and then sing to attract mates. Although the circuits that generate human speech are more complicated to decipher, the brains of songbirds offer a viable model for better understanding how humans learn to speak and what goes wrong in communication disorders such as autism.

An experimental antibody treatment that binds to a protein known as PCDH7 shrank tumors in preclinical models of non-small cell lung cancer (NSCLC), even those resistant to a targeted therapy, a study led by UT Southwestern Medical Center researchers showed.